Evidence map›Paper›PMID 31231710›Full record

ArticleCurrent opinion in physiology2019

A tale of ligands big and small: an update on how pentameric ligand-gated ion channels interact with agonists and proteins.

Stephan A Pless, Lucia G Sivilotti

Abstract read
In one paragraph

Article in Current opinion in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Massive Activation of GABABiomolecules · 2025
    Review
  3. Article
  4. GABABiophysical journal · 2024
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Stephan A PlessCenter for Biopharmaceuticals, Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark.
Lucia G SivilottiDepartment of Neuroscience, Physiology and Pharmacology, Division of Biosciences, University College London, Gower St, London WC1E 6BT, United Kingdom.
University College London · GBUniversity of Copenhagen · DK

Funding

Medical Research Council MR/J007110/1Medical Research Council MR/R009074/1
6 · The paper itself

Abstract

Pentameric ligand-gated ion channels (pLGICs, also known as Cys-loop receptors) are a large family of ion channels expressed in all

Indexed as

auxiliary subunitchaperoneIon channelligand bindingmembrane protein functiontoxin

Identifiers

PMID31231710
PMCPMC6588529
OpenAlexW2778612385

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.