ReviewNPJ microgravity2019
Limitations in predicting radiation-induced pharmaceutical instability during long-duration spaceflight.
Review in NPJ microgravity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Pilot degradation study of gamma irradiated ciprofloxacin in its primary packaging material for space pharmaceutical applications.Scientific reports · 2026Article
- Emerging Chemical and Biological Materials Technologies in the Extraplanetary Environment.Nano-micro letters · 2026Review
- Zero-gravity microbiome vortices: decoding orbital sepsis mimics and probiotic dysregulation in space health systems.Annals of medicine and surgery (2012) · 2025Article
- The long-term stability of solid-state oral pharmaceuticals exposed to simulated intravehicular space radiation.NPJ microgravity · 2025Article
- Repetitive stability study of remdesivir/cyclodextrin complex on the international space station.Scientific reports · 2025Article
- Acetaminophen production in the edible, filamentous cyanobacterium Arthrospira platensis.Biotechnology and bioengineering · 2025Article
- Pharmacist roles across the space mission pathway.Innovations in pharmacy · 2025Article
- Pharmacological Innovations in Space: Challenges and Future Perspectives.Pharmaceutical research · 2024Review
- Synergistic interplay between radiation and microgravity in spaceflight-related immunological health risks.Immunity & ageing : I & A · 2024Review
- Microalgae: towards human health from urban areas to space missions.Frontiers in plant science · 2024Article
- The effect of long-term spaceflight on drug potency and the risk of medication failure.NPJ microgravity · 2023Article
- Training and Education Requirements for Pharmacists in Zero Gravity Environments.Innovations in pharmacy · 2023Article
- To infinity and beyond: Strategies for fabricating medicines in outer space.International journal of pharmaceutics: X · 2022Article
- Space Medicines for Space Health.ACS medicinal chemistry letters · 2022Article
- Physiological adaptations affecting drug pharmacokinetics in space: what do we really know? A critical review of the literature.British journal of pharmacology · 2022Review
- Estimating medical risk in human spaceflight.NPJ microgravity · 2022Article
- Understanding the Complexities and Changes of the Astronaut Microbiome for Successful Long-Duration Space Missions.Life (Basel, Switzerland) · 2022Review
- Astropharmacy: Roles of Pharmacist in Space.Innovations in pharmacy · 2022Review
- Stability of Antimicrobial Drug Molecules in Different Gravitational and Radiation Conditions in View of Applications during Outer Space Missions.Molecules (Basel, Switzerland) · 2021Review
- The individual and combined effects of spaceflight radiation and microgravity on biologic systems and functional outcomes.Journal of environmental science and health. Part C, Toxicology and carcinogenesis · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As human spaceflight seeks to expand beyond low-Earth orbit, NASA and its international partners face numerous challenges related to ensuring the safety of their astronauts, including the need to provide a safe and effective pharmacy for long-duration spaceflight. Historical missions have relied upon frequent resupply of onboard pharmaceuticals; as a result, there has been little study into the effects of long-term exposure of pharmaceuticals to the space environment. Of particular concern are the long-term effects of space radiation on drug stability, especially as missions venture away from the protective proximity of the Earth. Here we highlight the risk of space radiation to pharmaceuticals during exploration spaceflight, identifying the limitations of current understanding. We further seek to identify ways in which these limitations could be addressed through dedicated research efforts aimed toward the rapid development of an effective pharmacy for future spaceflight endeavors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.