ReviewFrontiers in cardiovascular medicine2019
Preclinical Assessment of Cardiac Valve Substitutes: Current Status and Considerations for Engineered Tissue Heart Valves.
Review in Frontiers in cardiovascular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Preclinical Large AnimalCurrent cardiology reviews · 2023Pooled it
- Pooled it
- Large Animal Models for Preclinical Evaluation of Heart Valve Prostheses, Left Ventricular Assist Devices and Total Artificial Hearts: A Narrative Review.Biomimetics (Basel, Switzerland) · 2026Review
- Advancements and Perspectives in the Bioprosthetic Heart Valve: A Comprehensive Review on Biomaterial Processing and Emerging Polymeric Materials.Journal of the American Heart Association · 2025Review
- Dynamic blood compatibility assessment of coronary stents using an innovative pneumatic blood pump to generate physiological flow rates in small sample chambers.Journal of materials science. Materials in medicine · 2025Article
- A difference that matters: the aortic root anatomy of large animal models vs. humans.Frontiers in cardiovascular medicine · 2025Article
- Physiological basis for xenotransplantation from genetically modified pigs to humans.Physiological reviews · 2024Review
- Design and Analysis of a Polymeric Left Ventricular Simulator via Computational Modelling.Biomimetics (Basel, Switzerland) · 2024Article
- Evaluation of pliable bioresorbable, elastomeric aortic valve prostheses in sheep during 12 months post implantation.Communications biology · 2023Article
- New Insights into the Applications of 3D-Printed Biomaterial in Wound Healing and Prosthesis.AAPS PharmSciTech · 2023Review
- Isolation and Characterization of Porcine Endocardial Endothelial Cells.Tissue engineering. Part C, Methods · 2023Article
- Designing Biocompatible Tissue Engineered Heart Valves In Situ: JACC Review Topic of the Week.Journal of the American College of Cardiology · 2023Review
- Bicuspid Aortic Valve-Associated Regulatory Regions RevealArteriosclerosis, thrombosis, and vascular biology · 2023Article
- Correlations between the alpha-Gal antigen, antibody response and calcification of cardiac valve bioprostheses: experimental evidence obtained using an alpha-Gal knockout mouse animal model.Frontiers in immunology · 2023Article
- Physiologic Effects of Prolonged Terminal Anesthesia in Sheep (Comparative medicine · 2022Article
- Comparison of the function and structural integrity of cryopreserved pulmonary homografts versus decellularized pulmonary homografts after 180 days implantation in the juvenile ovine model.Cell and tissue banking · 2022Article
- A Biohybrid Material With Extracellular Matrix Core and Polymeric Coating as a Cell Honing Cardiovascular Tissue Substitute.Frontiers in cardiovascular medicine · 2022Article
- The effect of decellularisation on the real time mechanical fatigue of porcine aortic heart valve roots.PloS one · 2022Article
- Perspectives on pediatric congenital aortic valve stenosis: Extracellular matrix proteins, post translational modifications, and proteomic strategies.Frontiers in cardiovascular medicine · 2022Review
- The sheep as a pre-clinical model for testing intra-aortic percutaneous mechanical circulatory support devices.The International journal of artificial organs · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissue engineered heart valve (TEHV) technology may overcome deficiencies of existing available heart valve substitutes. The pathway by which TEHVs will undergo development and regulatory approval has several challenges. In this communication, we review: (1) the regulatory framework for regulation of medical devices in general and substitute heart valves in particular; (2) the special challenges of preclinical testing using animal models for TEHV, emphasizing the International Standards Organization (ISO) guidelines in document 5840; and (3) considerations that suggest a translational roadmap to move TEHV forward from pre-clinical to clinical studies and clinical implementation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.