Evidence map›Paper›PMID 31231648›Full record

ReviewFrontiers in cell and developmental biology2019

Hippo Signaling in Cancer: Lessons From

Kirti Snigdha, Karishma Sanjay Gangwani, Gauri Vijay Lapalikar, Amit Singh, Madhuri Kango-Singh

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 79 citations in OpenAlex.

  1. Embedded CRISPRi Enhances Gene-Silencing Efficiency in Drosophila.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. The Regulation and Function of Hippo/YAP Pathway in Cancer.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
  3. RASSF1A and its epigenetic dysregulation in genitourinary cancer: a current update.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  4. RAB40C regulates SNX9 stabilityCentral-European journal of immunology · 2026
    Article
  5. Medical science pulse · 2025
    Article
  6. Article
  7. Article
  8. Mitochondrial AAAFrontiers in cell and developmental biology · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Ferroptosis: An Emerging Target for Bladder Cancer Therapy.Current issues in molecular biology · 2023
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Kirti SnigdhaDepartment of Biology, University of Dayton, Dayton, OH, United States.
Karishma Sanjay GangwaniDepartment of Biology, University of Dayton, Dayton, OH, United States.
Gauri Vijay LapalikarDepartment of Biochemistry and Biophysics, Texas A&M University, College Station, TX, United States.
Amit SinghDepartment of Biology, University of Dayton, Dayton, OH, United States.
Madhuri Kango-SinghDepartment of Biology, University of Dayton, Dayton, OH, United States.
University of Dayton · USTexas A&M University · US

Funding

Genetic Basis of Patterning and Growth in Drosophila EyeR15GM124654 · NIGMS · UNIVERSITY OF DAYTON · PI SINGH, AMIT · 2017 to 2017
$439k
NIGMS NIH HHS R15 GM124654
6 · The paper itself

Abstract

Hippo pathway was initially identified through genetic screens for genes regulating organ size in fruitflies. Recent studies have highlighted the role of Hippo signaling as a key regulator of homeostasis, and in tumorigenesis. Hippo pathway is comprised of genes that act as tumor suppressor genes like

Indexed as

cancercell deathcell-polaritycell proliferationDrosophilahippo pathway

Identifiers

PMID31231648
PMCPMC6558396
OpenAlexW2945191715

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.