Evidence map›Paper›PMID 31231551›Full record

ArticleNPJ vaccines2019

HIV therapeutic vaccine enhances non-exhausted CD4

Vincent Vieillard, Béhazine Combadière, Roland Tubiana, Odile Launay, Gilles Pialoux, Laurent Cotte, Pierre-Marie Girard, Anne Simon, Yasmine Dudoit, Jacques Reynes and 12 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in NPJ vaccines, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Biotech's role in advancing HIV vaccine development.Emerging microbes & infections · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 13 institutions in 5 countries.

Vincent Vieillard *1Sorbonne Université, Inserm, CNRS, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France.
Béhazine Combadière *1Sorbonne Université, Inserm, CNRS, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France.
Roland Tubiana2AP-HP Pitié-Salpêtrière, Paris, France.
Odile Launay4AP-HP Cochin, Paris, France.
Gilles Pialoux5AP-HP Tenon, Paris, France.
Laurent Cotte6Hospices Civils de Lyon, Hôpital de la Croix-Rousse, Lyon, France.
Pierre-Marie Girard7AP-HP Saint-Antoine, Paris, France.
Anne Simon2AP-HP Pitié-Salpêtrière, Paris, France.
Yasmine Dudoit2AP-HP Pitié-Salpêtrière, Paris, France.
Jacques Reynes8Hôpital Gui de Chauliac, Montpellier, France.
Jürgen RockstrohUniversität Klinikum Bonn, Bonn, Germany.
Felipe Garcia11Hospital Clínic, Barcelona, Spain.
Jose Gatell12ViiV Healthcare, Brentford, UK.
Alain Devidas13Centre hospitalier Sud Francilien, Corbeil-Essonne, France.
Yazdan Yazdanpanah14AP-HP Bichat, Paris, France.
Laurence Weiss15AP-HP Hôpital Européen Georges Pompidou, Paris, France.
Gerd Fätkenheuer17Department 1 for Internal Medicine, University Hospital of Cologne, Cologne, Germany.
Brigitte Autran1Sorbonne Université, Inserm, CNRS, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France.
Delphine JoyeuxMinka Therapeutics, Paris, France.
Shahin GharakhanianPharmaceutical Medicine & Infectious Diseases, CIC: Cambridge Innovation Center, Cambridge, MA USA.
Patrice Debré1Sorbonne Université, Inserm, CNRS, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France.
Christine Katlama2AP-HP Pitié-Salpêtrière, Paris, France.
Assistance Publique – Hôpitaux de Paris · FRSorbonne Université · FRPitié-Salpêtrière Hospital · FRCentre Hospitalier Sud Francilien · FRGerman Center for Infection Research · DEHôpital Cochin · FRHôpital de la Croix-Rousse · FRHôpital Gui de Chauliac · FRHospital Clínic de Barcelona · ESInnovation Research Center · USInserm · FRUniversity Hospital Bonn · DEViiV Healthcare (United Kingdom) · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

VAC-3S is a therapeutic vaccine comprising a highly conserved HIV-gp41 motif coupled with the CRM197 carrier protein. High levels of anti-3S antibodies (Abs) have been associated with improved protection of CD4

Indexed as

Peptide vaccinesViral infection

Identifiers

PMID31231551
PMCPMC6546693
OpenAlexW2948963940

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.