Evidence map›Paper›PMID 31231539›Full record

ArticleMicrosystems & nanoengineering2019

Acoustofluidic separation of cells and particles.

Mengxi Wu, Adem Ozcelik, Joseph Rufo, Zeyu Wang, Rui Fang, Tony Jun Huang

Abstract read
In one paragraph

Article in Microsystems & nanoengineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 149 papers.

0numbers the graph read from it
0cells of the map it votes in
149citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

149 citing papers in PubMed.

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  15. Metamaterials and Fluid Flows.Nature communications · 2026
    Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review

89 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mengxi Wu1Department of Mechanical Engineering and Material Science, Duke University, Durham, NC 27708 USA.ORCID 0000-0003-0086-5349
Adem Ozcelik2Mechanical Engineering Department, Aydin Adnan Menderes University, 09010 Aydin, Turkey.ORCID 0000-0002-3124-795X
Joseph Rufo1Department of Mechanical Engineering and Material Science, Duke University, Durham, NC 27708 USA.
Zeyu Wang1Department of Mechanical Engineering and Material Science, Duke University, Durham, NC 27708 USA.
Rui Fang3Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138 USA.
Tony Jun Huang1Department of Mechanical Engineering and Material Science, Duke University, Durham, NC 27708 USA.ORCID 0000-0003-1205-3313

Funding

Extracellular vesicles and their ncRNA cargo as markers of trophoblast injuryR01HD086325 · NICHD · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI SADOVSKY, YOEL · 2015 to 2019
$3.6M
ExoSOUND: An Acoustofluidic Device for Exosome IsolationR44GM125439 · NIGMS · ASCENT BIO-NANO TECHNOLOGIES, INC. · PI WANG, LIN · 2017 to 2018
$1.9M
An integrated acoustofluidic droplet-sorting platform for classification of lymphocyte activity and functional phenotyping at single cell levelR01GM127714 · NIGMS · NORTHEASTERN UNIVERSITY · PI KONRY, TANIA TALI · 2018 to 2021
$1.2M
An Acoustofluidic Device for Biocompatible Platelet SeparationR43HL140800 · NHLBI · ASCENT BIO-NANO TECHNOLOGIES, INC. · PI WANG, LIN · 2018 to 2018
$225k
NHLBI NIH HHS R43 HL140800NICHD NIH HHS R01 HD086325NIGMS NIH HHS R01 GM127714NIGMS NIH HHS R44 GM125439
6 · The paper itself

Abstract

Acoustofluidics, the integration of acoustics and microfluidics, is a rapidly growing research field that is addressing challenges in biology, medicine, chemistry, engineering, and physics. In particular, acoustofluidic separation of biological targets from complex fluids has proven to be a powerful tool due to the label-free, biocompatible, and contact-free nature of the technology. By carefully designing and tuning the applied acoustic field, cells and other bioparticles can be isolated with high yield, purity, and biocompatibility. Recent advances in acoustofluidics, such as the development of automated, point-of-care devices for isolating sub-micron bioparticles, address many of the limitations of conventional separation tools. More importantly, advances in the research lab are quickly being adopted to solve clinical problems. In this review article, we discuss working principles of acoustofluidic separation, compare different approaches of acoustofluidic separation, and provide a synopsis of how it is being applied in both traditional applications, such as blood component separation, cell washing, and fluorescence activated cell sorting, as well as emerging applications, including circulating tumor cell and exosome isolation.

Indexed as

ChemistryEngineeringNanoscience and technology

Identifiers

PMID31231539
PMCPMC6545324

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.