ArticleIranian journal of basic medical sciences2019
Studying humane endpoints in a rat model of mammary carcinogenesis.
Article in Iranian journal of basic medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Cardiac Modulation byCurrent issues in molecular biology · 2026Article
- Effects of Ladder-Climbing Exercise on Mammary Cancer: Data from a Chemically Induced Rat Model.Veterinary sciences · 2025Article
- Successful hormonal and chemical induction of prostate cancer in a rat model: practical guidelines.Veterinary research forum : an international quarterly journal · 2024Review
- Realistic aspects behind the application of the rat model of chemically-induced mammary cancer: Practical guidelines to obtain the best results.Veterinary world · 2023Review
- Studying and Analyzing Humane Endpoints in the Fructose-Fed and Streptozotocin-Injected Rat Model of Diabetes.Animals : an open access journal from MDPI · 2023Article
- Disease Animal Models for Cancer Research.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Pulegone and Eugenol Oral Supplementation in Laboratory Animals: Results from Acute and Chronic Studies.Biomedicines · 2022Article
- IL-6 inhibitors effectively reverse post-infarction cardiac injury and ischemic myocardial remodeling via the TGF-β1/Smad3 signaling pathway.Experimental and therapeutic medicine · 2022Article
- GNG2 acts as a tumor suppressor in breast cancer through stimulating MRAS signaling.Cell death & disease · 2022Article
- Refinement of Animal Model of Colorectal Carcinogenesis through the Definition of Novel Humane Endpoints.Animals : an open access journal from MDPI · 2021Article
- Choosing The Right Animal Model for Renal Cancer Research.Translational oncology · 2020Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe present work intended to clearly define the most adequate humane endpoints in an experimental assay of mammary carcinogenesis in rats. MATERIALS AND
methodsAnimals were observed twice a day; all parameters were registered once a week and the euthanasia endpoints were established in order to monitor the animal welfare/distress during an experimental assay of chemically-induced mammary carcinogenesis in female rats.
resultsFourteen animals developed at least one mammary tumor with a diameter >35 mm. No animals exhibited alterations in the remaining parameters that implied their early sacrifice. Statistically significant changes were not observed in the quantitative parameters like the hematocrit and urine specific gravity among groups, not being valuable for the assessment of the health status of animals included in an assay of mammary carcinogenesis for 18 weeks. The remaining humane endpoints seemed to be helpful to monitor the animals' health status.
conclusionThe alteration in only one humane endpoint (mammary tumor dimensions) does not imply the animals' sacrifice; the endpoints should be evaluated in conjunction, in order to define the most adequate time in which the animals should be sacrificed.
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