Evidence map›Paper›PMID 31231487›Full record

ArticleIranian journal of basic medical sciences2019

Human leukocyte antigen (HLA)-Cw0303, HLA-Cw04, and HLA-Cw07 polymorphisms are associated with susceptibility of rheumatoid arthritis in Chinese Han patients from Southern China.

Chuankun Yang, Chunling Wang, Yan Shi, Li Li

Open access · greenAbstract read
In one paragraph

Article in Iranian journal of basic medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Chuankun YangDepartment of Immunology Laboratory, Zhongda Hospital, School of medicine, Southeast University, Nanjing, Jiangsu, 210009, China.
Chunling WangDepartment of Immunology Laboratory, Zhongda Hospital, School of medicine, Southeast University, Nanjing, Jiangsu, 210009, China.
Yan ShiDepartment of Immunology Laboratory, Zhongda Hospital, School of medicine, Southeast University, Nanjing, Jiangsu, 210009, China.
Li LiDepartment of Immunology Laboratory, Zhongda Hospital, School of medicine, Southeast University, Nanjing, Jiangsu, 210009, China.
Zhongda Hospital Southeast University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aimed to investigate the association between human leukocyte antigen Cw (HLA-Cw) polymorphisms and rheumatoid arthritis (RA) in Chinese Han patients in the Jiangsu area (Southern China). MATERIALS AND

methodsPolymerase chain reaction-sequence specific primers were used to detect HLA-Cw01-08 of 201 RA patients and 211 healthy individuals from Zhongda Hospital (China). The allele frequency distribution of HLA-Cw and genotypic differences between the two groups were analyzed.

resultsThe frequency of HLA-Cw0303 in patients with RA was significantly higher than that in controls, while the frequency of HLA-Cw04 was lower than that in controls (

conclusionThese results suggest that HLA-Cw0303 is a susceptibility gene for RA in Chinese Han patients in the Jiangsu area of southern China. The HLA-Cw04 gene may be a protective factor against RA, while HLA-Cw07 might play a protective role in the production of anti-CCP in the long-term course in patients with RA.

Indexed as

Anti-citrullinated protein – antibodiesArthritis rheumatoidGene frequencyHLA antigensPolymorphismSingle nucleotide

Identifiers

PMID31231487
PMCPMC6570748
OpenAlexW2935741492

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.