Evidence map›Paper›PMID 31231387›Full record

ArticleFrontiers in immunology2019

Enhanced Bone Marrow Homing of Natural Killer Cells Following mRNA Transfection With Gain-of-Function Variant CXCR4

Emily Levy, Robert Reger, Filip Segerberg, Melanie Lambert, Caroline Leijonhufvud, Yvonne Baumer, Mattias Carlsten, Richard Childs

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 79 citations in OpenAlex.

  1. Article
  2. Advances inMolecular therapy. Nucleic acids · 2026
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  6. Challenges and opportunities of human iPSC-derived NK as "Off-the-shelf" cellular therapies.Journal of experimental & clinical cancer research : CR · 2025
    Review
  7. Article
  8. Review
  9. Review
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  11. Article
  12. Natural killer cell-based immunotherapy for cancer.Journal of immunology (Baltimore, Md. : 1950) · 2025
    Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Empowering Natural Killer Cells to Combat Acute Myeloid Leukemia: Perspective on CAR-NK Cell Therapy.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Emily LevyNational Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Robert RegerNational Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Filip SegerbergDepartment of Medicine, Huddinge, Center for Hematology and Regenerative Medicine, Karolinska Institutet, Stockholm, Sweden.
Melanie LambertDepartment of Medicine, Huddinge, Center for Hematology and Regenerative Medicine, Karolinska Institutet, Stockholm, Sweden.
Caroline LeijonhufvudDepartment of Medicine, Huddinge, Center for Hematology and Regenerative Medicine, Karolinska Institutet, Stockholm, Sweden.
Yvonne BaumerNational Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Mattias CarlstenNational Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Richard ChildsNational Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
National Heart Lung and Blood Institute · USKarolinska Institutet · SENational Institutes of Health · US

Funding

Allogeneic Immunotherapy for cancer and nonmalignant hematological disordersZIAHL002345 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI CHILDS, RICHARD · 2009 to 2025
$53.3M
6 · The paper itself

Abstract

Adoptive transfer of natural killer (NK) cells can induce remission in patients with relapsed/refractory leukemia and myeloma. However, to date, clinical efficacy of NK cell immunotherapy has been limited to a sub-fraction of patients. Here we show that steps incorporated in the

Indexed as

Gain of Function MutationTransfectionAmino Acid SubstitutionAnimalsBone MarrowHeterograftsHumansKiller Cells, NaturalMiceMice, Inbred NODMice, SCIDReceptors, CXCR4RNA, MessengerCXCR4 protein, humanReceptors, CXCR4RNA, MessengerCXCR4homingimmunotherapymRNA transfectionNK cellsWHIM

Identifiers

PMID31231387
PMCPMC6560173
OpenAlexW2965141141

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.