Evidence map›Paper›PMID 31231363›Full record

ArticleFrontiers in immunology2019

Gut Microbiota Regulates Mincle Mediated Activation of Lung Dendritic Cells to Protect Against

Shikha Negi, Susanta Pahari, Hilal Bashir, Javed N Agrewala

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04447144 (Nutritional Habits, Does it Affect Coronavirus Disease 2019), which is not on this map. Cited by 67 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 3 pooled it
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04447144 unknown statusnot on this mapstarted 2020, after this paper: background citation

Nutritional Habits, Does it Affect Coronavirus Disease 2019 (COVID-19) Infection Outcome? An Egyptian Experience

TypeobservationalSponsorCairo UniversityRan2020 to 2020Enrolled200ConditionsCovid19, Chronic Inflammation, Non-Communicable Chronic Diseases
3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 3 syntheses or guidelines pooled it, 110 citations in OpenAlex.

  1. Pooled it
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  3. Pooled it
  4. Review
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  6. Article
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  8. Article
  9. Effects of dietaryJDS communications · 2026
    Article
  10. Review
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  12. Review
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  19. Review
  20. Gut-X axis.iMeta · 2025
    Review

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Shikha NegiImmunology Division, CSIR-Institute of Microbial Technology, Chandigarh, India.
Susanta PahariImmunology Division, CSIR-Institute of Microbial Technology, Chandigarh, India.
Hilal BashirImmunology Division, CSIR-Institute of Microbial Technology, Chandigarh, India.
Javed N AgrewalaImmunology Division, CSIR-Institute of Microbial Technology, Chandigarh, India.
Institute of Microbial Technology · INTexas Biomedical Research Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gut microbial components serve as ligand for various pattern recognition receptors (PRRs) present on immune cells and thereby regulates host immunity. Dendritic cells (DCs) are highly specialized innate cells involved in immune response to

Indexed as

AnimalsAnti-Bacterial AgentsCD4-Positive T-LymphocytesDendritic CellsDysbiosisGastrointestinal MicrobiomeGlycolipidsImmunity, InnateLactobacillusLectins, C-TypeLungMacrophagesMembrane ProteinsMice, Inbred C57BLMice, KnockoutMycobacterium tuberculosisAnti-Bacterial AgentsClecsf8 protein, mouseGlycolipidsLectins, C-TypeMembrane ProteinsReceptors, Pattern Recognitiontrehalose 6,6'-dibehenateantibioticsgut-lung axislung dendritic cellsmincleT cellstuberculosis

Identifiers

PMID31231363
PMCPMC6558411
OpenAlexW2947723870

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.