Evidence map›Paper›PMID 31231214›Full record

ArticleFrontiers in pharmacology2019

Deacylcynaropicrin Inhibits RANKL-Induced Osteoclastogenesis by Inhibiting NF-κB and MAPK and Promoting M2 Polarization of Macrophages.

Zhikun Li, Xiaodong Zhu, Ruijun Xu, Yi Wang, Ruixi Hu, Wei Xu

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
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  6. Frontiers in pharmacology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Zhikun LiDepartment of Orthopaedics, TongRen Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China.
Xiaodong ZhuDepartment of Orthopaedics, TongRen Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China.
Ruijun XuDepartment of Orthopaedics, TongRen Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China.
Yi WangDepartment of Orthopaedics, TongRen Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China.
Ruixi HuDepartment of Orthopaedics, TongRen Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China.
Wei XuDepartment of Orthopaedics, TongRen Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China.
Shanghai Jiao Tong University · CNTongren Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammation can promote the maturity of osteoclasts and bone resorption in many bone disease such as osteoporosis and arthritis. Here, we aimed to investigate the inhibitory effects of deacylcynaropicrin (DAC) on osteoclastogenesis and bone resorption induced by RANKL. Bone-marrow-derived macrophages were used for assessing the influence of DAC on polarization of macrophages and osteoclastogenesis

Indexed as

deacylcynaropicrinmacrophagesMAPKNF-κBosteoclastogenesis

Identifiers

PMID31231214
PMCPMC6567936
OpenAlexW2950358746

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.