ArticleJournal of atherosclerosis and thrombosis2020
Effect of Metabolically Healthy Obesity on the Development of Carotid Plaque in the General Population: A Community-Based Cohort Study.
Article in Journal of atherosclerosis and thrombosis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Metabolic health phenotypes and cardiovascular disease among U.S. adults with central obesity: Evidence from NHANES 2011- March 2020.Obesity pillars · 2026Article
- Population attributable fraction of modifiable risk factors for incident hypertension: an analysis of large-scale epidemiological cohort.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Comparison of deep learning reconstruction and iterative reconstruction algorithms for virtual monoenergetic image quality in overweight and obese patients with triple-low scan protocol dual-energy carotid computed tomography angiography.Quantitative imaging in medicine and surgery · 2026Article
- Obesity-Driven Segment-Specific Cerebrovascular Remodeling: A 3D High-Resolution Vessel Wall Imaging Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Metabolically Abnormal Obesity and Carotid Plaque Vulnerability: A Vessel Wall MRI Study Linking Obesity Phenotypes to Atherosclerotic Instability.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- Metabolic syndrome and cardiovascular disease in cancer survivors.Journal of cachexia, sarcopenia and muscle · 2024Article
- Sex Differences in the Association Between Depression and Incident Cardiovascular Disease.JACC. Asia · 2024Article
- Sex Differences in the Relationship Between Schizophrenia and the Development of Cardiovascular Disease.Journal of the American Heart Association · 2024Article
- Association of metabolically unhealthy non-obese and metabolically healthy obese individuals with arterial stiffness and 10-year cardiovascular disease risk: a cross-sectional study in Chinese adults.Nutrition journal · 2023Article
- Age-Dependent Association Between Modifiable Risk Factors and Incident Cardiovascular Disease.Journal of the American Heart Association · 2023Article
- Metabolically Healthy Obesity and Carotid Plaque among Steelworkers in North China: The Role of Inflammation.Nutrients · 2022Article
- Incorporation of Retinal Arteriolosclerosis into Risk Stratification of Blood Pressure Category According to the 2017 ACC/AHA Blood Pressure Guideline.Journal of atherosclerosis and thrombosis · 2022Article
- Relationship of normal-weight central obesity with the risk for heart failure and atrial fibrillation: analysis of a nationwide health check-up and claims database.European heart journal open · 2022Article
- Transition from metabolically healthy to unhealth status associated with risk of carotid artery plaque in Chinese adults.BMC cardiovascular disorders · 2021Article
- Promoting analysis of real-world data: Prospects for preventive cardiology in Japan.Global health & medicine · 2021Review
- A favorable metabolic profile in metabolically healthy obesity is associated with physical activity level rather than abdominal fat volume in Japanese males.Journal of physical therapy science · 2021Article
- Association of Isolated Diastolic Hypertension Based on the Cutoff Value in the 2017 American College of Cardiology/American Heart Association Blood Pressure Guidelines With Subsequent Cardiovascular Events in the General Population.Journal of the American Heart Association · 2020Observational
- Diabetes and carotid artery disease: a narrative review.Annals of translational medicine · 2020Review
- Effect of cigarette smoking on carotid artery atherosclerosis: a community-based cohort study.Heart and vessels · 2020Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimObesity and metabolic syndrome (MetS) frequently coexist and are both important risk factors for cardiovascular disease. However, the pathophysiological role of obesity without MetS, also referred to as metabolically healthy obesity (MHO), remains unclear. In this study, we aim to clarify the effect of MHO on the development of carotid plaque using a community-based cohort.
methodsWe examined 1,241 subjects who underwent health checkups at our institute. Obesity was defined as body mass index of ≥ 25.0 kg/m
resultsThe prevalence of carotid plaque, defined as intima-media thickness (IMT) ≥ 1.1 mm, was higher in subjects with MUO and MHO than in non-obese subjects. Multivariable analysis demonstrated that MHO (odds ratio 1.6, p=0.012) and MUO (odds ratio 1.9, p=0.003) as well as age of ≥ 65 years, male sex, hypertension, and diabetes mellitus were independently associated with carotid plaque formation. A similar trend was observed in each subgroup according to age and sex.
conclusionsMHO increased the prevalence of carotid plaque when compared with non-obese subjects, suggesting the potential significance of MHO in the development of subsequent cardiovascular diseases.
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