ArticleCurrent biology : CB2019
Immediate Dosage Compensation Is Triggered by the Deletion of Y-Linked Genes in Silene latifolia.
Article in Current biology : CB, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Developmental robustness of the shoot apical meristem despite sex-chromosome dosage imbalance in Silene latifolia.BMC plant biology · 2026Article
- Silene, a versatile model system: from sex and genome evolution to ecology and speciation.The New phytologist · 2026Review
- HJ Muller and the Relationship Between Sex Chromosome Degeneration and the Evolution of Dosage Compensation.Genome biology and evolution · 2025Review
- Extensive Recombination Suppression and Genetic Degeneration of a Young ZW Sex Chromosome System in Halfbeak Fish.Molecular biology and evolution · 2025Article
- Effect of heterozygous deletions on phenotypic changes and dosage compensation in Arabidopsis thaliana.Scientific reports · 2025Article
- Sex Chromosome Evolution: Hallmarks and Question Marks.Molecular biology and evolution · 2024Review
- Non-canonical bases differentially represented in the sex chromosomes of the dioecious plant Silene latifolia.Journal of experimental botany · 2024Article
- Why should we study plant sex chromosomes?The Plant cell · 2024Review
- Genomic view of heavy-ion-induced deletions associated with distribution of essential genes inFrontiers in plant science · 2024Article
- Evolution of sex-determination in dioecious plants: From active Y to X/A balance?BioEssays : news and reviews in molecular, cellular and developmental biology · 2023Article
- The origin and evolution of sex chromosomes, revealed by sequencing of the Silene latifolia female genome.Current biology : CB · 2023Article
- A CLAVATA3-like Gene Acts as a Gynoecium Suppression Function in White Campion.Molecular biology and evolution · 2022Article
- Dosage compensation evolution in plants: theories, controversies and mechanisms.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Epigenetics drive the evolution of sex chromosomes in animals and plants.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Transcriptional regulation of dosage compensation in Carica papaya.Scientific reports · 2021Article
- Gene-Level, but Not Chromosome-Wide, Divergence between a Very Young House Fly Proto-Y Chromosome and Its Homologous Proto-X Chromosome.Molecular biology and evolution · 2021Article
- Evidence for Dosage Compensation inGenes · 2020Article
- The Location of the Pseudoautosomal Boundary inGenes · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The loss of functional genes from non-recombining sex-specific chromosomes [1, 2], such as the Y chromosomes in mammals [3] or W chromosomes in birds [4], should result in an imbalance of gene products for sex-linked genes [5]. Different chromosome-wide systems that rebalance gene expression are known to operate in organisms with relatively old sex chromosomes [6]; e.g., Drosophila overexpress X-linked genes in males [7], while mammals shut down one of the X chromosomes in females [8]. It is not known how long it takes for a chromosome-wide dosage compensation system to evolve. To shed light on the early evolution of dosage compensation, we constructed a high-density Y-deletion map and used deletion mutants to manipulate gene dose and analyze gene expression in white campion (Silene latifolia), which evolved dioecy and sex chromosomes only 11 million years ago [9]. We demonstrate that immediate dosage compensation can be triggered by deletions in a large portion of the p arm of the Y chromosome. Our results indicate that dosage compensation in S. latifolia does not have to evolve gene by gene because a system to upregulate gene expression is already operating on part of the X chromosome, which likely represents an intermediate step in the evolution of a chromosome-wide dosage compensation system in this species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.