Trial reportInternational journal of cardiology2019
Incidence, determinants and impact of acute kidney injury in patients with diabetes mellitus and multivessel disease undergoing coronary revascularization: Results from the FREEDOM trial.
Trial report in International journal of cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Risk factors for acute kidney injury after coronary artery bypass graft surgery: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Determinants of stroke following percutaneous coronary intervention in patients with acute coronary syndrome: a systematic review and meta-analysis.Annals of medicine · 2025Pooled it
- Diabetes does not modify the renal-protective effect of intravenous amino acids infusion after cardiac surgery.Journal of endocrinological investigation · 2026Trial
- CIN-RiskNet: a dynamic feature-enhanced TabTransformer with hybrid SMOTE-noise augmentation for contrast-induced nephropathy prediction.Frontiers in cardiovascular medicine · 2026Article
- Coronary Artery Bypass Grafting: A Review of Short- and Long-Term Outcomes.The International journal of angiology : official publication of the International College of Angiology, Inc · 2025Review
- Left main percutaneous or surgical revascularisation and subsequent risk of transient and persistent renal dysfunction.Open heart · 2025Article
- Article
- Acute kidney injury in diabetes mellitus: Epidemiology, diagnostic, and therapeutic concepts.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023Review
- Development and validation of short-term renal prognosis prediction model in diabetic patients with acute kidney injury.Diabetology & metabolic syndrome · 2022Article
- Cardiac Surgery-associated Acute Kidney Injury in Patients with Preserved Baseline Renal Function.Brazilian journal of cardiovascular surgery · 2022Article
- Timing of AKI after urgent percutaneous coronary intervention and clinical outcomes: a high-dimensional propensity score analysis.BMC nephrology · 2021Article
- Diabetes in Patients With Heart Failure With Reduced Ejection Fraction During Hospitalization: A Retrospective Observational Study.Frontiers in endocrinology · 2021Observational
- Article
- On-pump versus off-pump coronary artery bypass surgery for multi-vessel coronary revascularization.Journal of thoracic disease · 2020Article
Corrections and comments
- Commented on by
Authors and funding
6 authors at 4 institutions in 4 countries.
Funding
Abstract
backgroundThe incidence and prognostic significance of acute kidney injury (AKI) in patients with diabetes mellitus and multivessel coronary artery disease undergoing coronary revascularization is not well known. The current analysis included patients randomized to PCI vs. CABG as part of the FREEDOM trial. We sought to examine the impact of AKI and its predictors in diabetic patients with multivessel coronary artery disease undergoing PCI vs. CABG.
methodsWe conducted a pre-specified subgroup analysis of the FREEDOM trial to examine the incidence, correlates and impact of AKI according to revascularization strategy. AKI predictors were identified using multivariable logistic regression and associations between AKI and outcomes were examined using Cox regression. The primary endpoint was the composite occurrence of all-cause death, stroke or myocardial infarction at 5 years of follow-up.
resultsKI occurred more frequently in patients following CABG (15.6%) compared with PCI (9.1%) (p < 0.001). AKI was associated with a higher risk for major cardiovascular events (MACE) at 5 years (34.6% vs. 20.5%, p < 0.001), an effect that remained large and significant irrespective of CABG (HR = 2.18 95% CI 1.44-3.31, p ≤0.001) or PCI (HR = 2.08 95% CI 1.35-3.21, p < 0.0001). There was a non-significant interaction (p-value = 0.89) between the revascularization method and AKI, supporting that AKI is a significant risk factor in both revascularization methods.
conclusionsAlthough risk for AKI was higher in patients undergoing CABG, the impact of AKI on MACE was substantial irrespective of revascularization strategy. Preventive strategies to identify patients at risk for AKI are warranted to mitigate the long-term effects of this complication.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.