ArticleNeuron2019
The Autism-Associated Gene Scn2a Contributes to Dendritic Excitability and Synaptic Function in the Prefrontal Cortex.
Open access · greenAbstract readComparative Study
In one paragraph
Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 151 papers.
0numbers the graph read from it
0cells of the map it votes in
151citing papers in PubMed
19.2field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
151 citing papers in PubMed, 254 citations in OpenAlex.
- mTORC2-NaChannels (Austin, Tex.) · 2026Article
- Tannic Acid Mitigates Monosodium Glutamate-Induced Cortical Damage by Modulating Synaptic and Calcium-Related Gene and Protein Expression.Journal of applied toxicology : JAT · 2026Article
- Nonsense-mediated decay influences position-dependent effects of SCN2A premature stop codons on neuronal excitability and behavior.Molecular psychiatry · 2026Article
- Autism-associated SCN2A deficiency disrupts cortico-striatal circuitry in human brain assembloids.Neuron · 2026Article
- Gene therapy with doxycycline-controlled expression of human Kv1.1 reduces neuronal excitability and increases sociability ofbioRxiv : the preprint server for biology · 2026Article
- Transcriptome of fetal cortex of tree shrew underlying the emergence of outer subventricular zone.Communications biology · 2026Article
- Loss of schizophrenia risk gene XPO7 disrupts neuronal excitability and network regularity via altered NaMolecular psychiatry · 2026Article
- Voltage-Gated Sodium Channel NaBiochemical genetics · 2026Article
- Fever-like temperatures improve cognitive deficits in the Scn2a autism mouse model via increases in potassium channel activity.Molecular psychiatry · 2026Article
- Subcortical Dendritic Scaffolding in Autism Spectrum Disorder: A Testable ANK2-SCN2A-SHANK Framework.International journal of molecular sciences · 2026Review
- Accurately fitting biophysical neuron models to experimental voltage data enabled by meta-learning.Research square · 2026Article
- Voltage-gated sodium channels in the nervous system: Molecular physiology to therapeutic interventions.Neural regeneration research · 2026Article
- Excitatory Dysfunction and Phenotypic Rescue in a Human Neuronal Model ofbioRxiv : the preprint server for biology · 2026Article
- Article
- Sh3rf3 Deficiency drives autism-like behaviors via presynaptic dysfunction in mice.Molecular psychiatry · 2026Article
- Axon Initial Segment: Structure, Biological Functions, Diseases, and Therapeutic Targets.MedComm · 2026Review
- Behavioral and Prefrontal Circuit Deficits in a Newly DevelopedBiological psychiatry global open science · 2026Article
- A silent Kv channel subunit shapes PV neuron action potential waveform and short-term synaptic plasticity during high-frequency firing.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Functional Characterization of a De NovoNeurology. Genetics · 2026Article
- Dysregulation of miRNAs in Sicilian Patients with Autism Spectrum Disorder.Biomedicines · 2026Article
91 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on byLoss of Na2019
Authors and funding
7 authors at 1 institution in 1 country.
Perry W E SprattWeill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Roy Ben-ShalomWeill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Caroline M KeeshenWeill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Kenneth J BurkeWeill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Rebecca L ClarksonWeill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Stephan J SandersWeill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA.
Kevin J BenderWeill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. Electronic address: kevin.bender@ucsf.edu.
University of California, San Francisco · US
Funding
Mechanisms of Brain Dysmorphology in MN1 C-Terminal Truncation Syndrome, a Novel Intellectual Developmental Disability Disorder P50HD103524 · NICHD · UNIVERSITY OF WASHINGTON · PI DANIEL DOHERTY · 2020 to 2026
$9.9MCellular mechanisms for dopaminergic control of learning in prefrontal cortexR01DA035913 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BENDER, KEVIN J · 2013 to 2017
$1.7M3/3 Integrative Genomic Analysis of Human Brain Development and AutismR01MH110928 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SANDERS, STEPHAN, STATE, MATTHEW W. · 2016 to 2019
$1.3MFunction and regulation of action potential bursts in the auditory system.R00DC011080 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BENDER, KEVIN J · 2012 to 2014
$734kTowards a unified model of action potential generationF32NS095580 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BEN-SHALOM, ROY · 2015 to 2018
$172kNICHD NIH HHS P50 HD103524NIDA NIH HHS R01 DA035913NIDCD NIH HHS R00 DC011080NIMH NIH HHS R01 MH110928NINDS NIH HHS F32 NS095580
Abstract
Autism spectrum disorder (ASD) is strongly associated with de novo gene mutations. One of the most commonly affected genes is SCN2A. ASD-associated SCN2A mutations impair the encoded protein Na
Indexed as
Action Potentialsalpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnimalsAutism Spectrum DisorderCalcium SignalingDendritesFemaleGene Expression Regulation, DevelopmentalHeterozygoteHippocampusMaleMaze LearningMiceMiniature Postsynaptic PotentialsNAV1.2 Voltage-Gated Sodium ChannelNeocortexalpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidNAV1.2 Voltage-Gated Sodium ChannelN-MethylaspartateScn2a protein, mouse2-photon imagingaction potential backpropagationautism spectrum disorderdendritic excitabilityelectrophysiologyhaploinsufficiencyintellectual disabilityNaV1.2Scn2asodium channelsynaptic plasticity
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.