ArticleBiological psychiatry2019
Physician-Training Stress and Accelerated Cellular Aging.
Article in Biological psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Physical Activity on Telomere Length as a Biomarker for Aging: A Systematic Review.Sports medicine - open · 2022Pooled it
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- Impact of a Wellness Leadership Intervention on the Empathy, Burnout, and Resting Heart Rate of Medical Faculty.Mayo Clinic proceedings. Innovations, quality & outcomes · 2023Article
- Veterinarian burnout demographics and organizational impacts: a narrative review.Frontiers in veterinary science · 2023Review
- An exploratory analysis of leukocyte telomere length among pregnant and non-pregnant people.Brain, behavior, & immunity - health · 2022Article
- Adverse childhood experiences and perceived stress in early adulthood in the context of disadvantage.Child abuse & neglect · 2022Article
- Prescribing Sleep: An Overlooked Treatment for Postpartum Depression.Biological psychiatry · 2022Article
- The Impact of Orthopaedic Surgical Training on Body Composition.The Iowa orthopaedic journal · 2022Article
- Leukocyte telomere dynamics across gestation in uncomplicated pregnancies and associations with stress.BMC pregnancy and childbirth · 2022Article
- Family Financial Pressure in Childhood and Telomere Length in Early Adolescence: A Prospective Study.Genes · 2022Article
- Cellular Senescence Affects Cardiac Regeneration and Repair in Ischemic Heart Disease.Aging and disease · 2021Review
- Article
- Perceived Surgeon Stress During No-Sedation Topical Phacoemulsification.Clinical ophthalmology (Auckland, N.Z.) · 2020Article
- Telomeres, Trauma, and Training.Biological psychiatry · 2019Article
- Systemic Immune Dyshomeostasis Model and Pathways in Alzheimer's Disease.Frontiers in aging neuroscience · 2019Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundStress is a key precipitant for many common diseases, but established biological markers to track stress and guide investigations into mechanisms linking stress and disease are lacking. Cross-sectional studies have identified correlations between stress and telomere attrition, but no large, longitudinal studies examining the impacts of chronic stress on telomere length exist. Residency training for physicians is a well-established stressful experience and can be used as a prospective stress model.
methodsIn a longitudinal cohort study of 250 interns (first-year residents) at 55 United States hospital systems serving during the 2015-2016 academic year, we examined associations between measures of the residency experience and saliva-measured telomere attrition.
resultsTelomere length shortened significantly over the course of internship year, from mean ± SD of 6465.1 ± 876.8 base pairs before internship to 6321.5 ± 630.6 base pairs at the end of internship (t
conclusionsThis work implicates telomere attrition as a biologically measurable consequence of physician training, with the magnitude of attrition associated with workload. Identification of an objective, biological sequela of residency stress may help to facilitate the development of effective interventions. Further, the findings implicate telomere attrition as an objective biomarker to follow the pathologic effects of stress, in general.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.