SynthesisHypertension (Dallas, Tex. : 1979)2019
Hypertensive Disorders of Pregnancy and DNA Methylation in Newborns.
Open access · greenAbstract readMeta-AnalysisReview
In one paragraph
Synthesis in Hypertension (Dallas, Tex. : 1979), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 6 pooled it
23.0field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
67 citing papers in PubMed, 6 syntheses or guidelines pooled it, 133 citations in OpenAlex.
- Maternal hypertensive disorders during pregnancy and their link to childhood asthma: a systematic review and meta-analysis.Frontiers in pediatrics · 2025Pooled it
- DNA methylation sites in early adulthood characterised by pubertal timing and development: a twin study.Clinical epigenetics · 2023Pooled it
- Cord blood epigenome-wide meta-analysis in six European-based child cohorts identifies signatures linked to rapid weight growth.BMC medicine · 2023Pooled it
- Maternal Mediterranean diet in pregnancy and newborn DNA methylation: a meta-analysis in the PACE Consortium.Epigenetics · 2022Pooled it
- Maternal Hypertensive Pregnancy Disorders and Mental and Behavioral Disorders in the Offspring: a Review.Current hypertension reports · 2021Pooled it
- Previous preeclampsia and its association with the future development of cardiovascular diseases: a systematic review and meta-analysis.Clinics (Sao Paulo, Brazil) · 2021Pooled it
- Impact of Maternal Aspirin Therapy on Neonatal Epigenetic Patterns.American journal of perinatology · 2026Article
- Maternal-Fetal Crosstalk in Cardiovascular Programming: Linking the Intrauterine Environment to Lifelong Disease Risk.Journal of cardiovascular development and disease · 2026Review
- Placental molecular subtypes of severe preeclampsia reveal divergent aging trajectories and fetal growth outcomes.medRxiv : the preprint server for health sciences · 2026Article
- Leptin-specific epigenetic modulation of preterm cord blood serves as a candidate biomarker for obesity.Pediatric research · 2026Article
- Association of DNA methylation with hypertension and blood pressure: a 7-year longitudinal study from KORA F4/FF4.BMC medicine · 2026Article
- Cord blood DNA methylation and cell-type composition are not significantly associated with severe preeclampsia after cell-type and clinical covariate adjustment.GigaScience · 2026Article
- Prenatal factors shaping adolescent cardiovascular function and cardiometabolic risk trajectories.Frontiers in pediatrics · 2026Review
- Role of epigenetic markers in cardiovascular disease following hypertensive disorders of pregnancy.Epigenomics · 2025Review
- DNA methylation and telomere length in 2-5 year olds with intrauterine preeclampsia exposure: a P4 sub-study.Clinical epigenetics · 2025Article
- Cell type proportions rather than DNA methylation in the cord blood show significant associations with severe preeclampsia.medRxiv : the preprint server for health sciences · 2025Article
- PedBE age and age acceleration in umbilical vein endothelial cells: an examination of infant birth outcomes.Journal of developmental origins of health and disease · 2025Article
- Early life epigenetics and childhood outcomes: a scoping review.Pediatric research · 2025Article
- The correlation between sperm DNA methylation and DNA damage: a comparison of comet and TUNEL.Frontiers in reproductive health · 2025Article
- Genetics of glucose homeostasis in pregnancy and postpartum.Diabetologia · 2024Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
43 authors at 19 institutions in 8 countries.
Nabila KazmiFrom the MRC Integrative Epidemiology Unit (N.K., G.C.S., A.J.S., K.B., T.G.R., D.L.S.F., A.F., M.C.M., T.I.A.S., T.R.G., D.A.L., C.L.R.), University of Bristol, United Kingdom.
Gemma C SharpFrom the MRC Integrative Epidemiology Unit (N.K., G.C.S., A.J.S., K.B., T.G.R., D.L.S.F., A.F., M.C.M., T.I.A.S., T.R.G., D.A.L., C.L.R.), University of Bristol, United Kingdom.
Sarah E ReeseDivision of Intramural Research, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC (S.E.R., Q.E.H., S.Z., S.J.L.).
Florianne O VehmeijerThe Generation R Study Group (F.O.V., V.W.V.J., J.F.F.), Erasmus MC, University Medical Center Rotterdam, the Netherlands.
Jari LahtiDepartment of Psychology and Logopedics, Faculty of Medicine (J.L., K.R.), University of Helsinki, Finland.
Christian M PageDivision of Mental and Physical Health (C.M.P., W.N.), Norwegian Institute of Public Health, Oslo.
Weiming ZhangDepartment of Biostatistics and Informatics (W.Z., K.J.K.), University of Colorado Anschutz Medical Campus, Aurora.
Sheryl L Rifas-ShimanDepartment of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA (S.L.R.-S., E.O., M.-F.H.).
Faisal I RezwanHuman Development and Health (F.I.R., J.W.H.), Faculty of Medicine University of Southampton, United Kingdom.
Andrew J SimpkinFrom the MRC Integrative Epidemiology Unit (N.K., G.C.S., A.J.S., K.B., T.G.R., D.L.S.F., A.F., M.C.M., T.I.A.S., T.R.G., D.A.L., C.L.R.), University of Bristol, United Kingdom.
Kimberley BurrowsFrom the MRC Integrative Epidemiology Unit (N.K., G.C.S., A.J.S., K.B., T.G.R., D.L.S.F., A.F., M.C.M., T.I.A.S., T.R.G., D.A.L., C.L.R.), University of Bristol, United Kingdom.
Tom G RichardsonFrom the MRC Integrative Epidemiology Unit (N.K., G.C.S., A.J.S., K.B., T.G.R., D.L.S.F., A.F., M.C.M., T.I.A.S., T.R.G., D.A.L., C.L.R.), University of Bristol, United Kingdom.
Diana L Santos FerreiraFrom the MRC Integrative Epidemiology Unit (N.K., G.C.S., A.J.S., K.B., T.G.R., D.L.S.F., A.F., M.C.M., T.I.A.S., T.R.G., D.A.L., C.L.R.), University of Bristol, United Kingdom.
Abigail FraserFrom the MRC Integrative Epidemiology Unit (N.K., G.C.S., A.J.S., K.B., T.G.R., D.L.S.F., A.F., M.C.M., T.I.A.S., T.R.G., D.A.L., C.L.R.), University of Bristol, United Kingdom.
Quaker E HarmonDivision of Intramural Research, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC (S.E.R., Q.E.H., S.Z., S.J.L.).
Shanshan ZhaoDivision of Intramural Research, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC (S.E.R., Q.E.H., S.Z., S.J.L.).
Vincent W V JaddoeThe Generation R Study Group (F.O.V., V.W.V.J., J.F.F.), Erasmus MC, University Medical Center Rotterdam, the Netherlands.
Darina CzamaraDepartment of Translational Research in Psychiatry, Max-Planck Institute of Psychiatry, Munich, Germany (D.C., E.B.B.).
Elisabeth B BinderDepartment of Translational Research in Psychiatry, Max-Planck Institute of Psychiatry, Munich, Germany (D.C., E.B.B.).
Maria C MagnusFrom the MRC Integrative Epidemiology Unit (N.K., G.C.S., A.J.S., K.B., T.G.R., D.L.S.F., A.F., M.C.M., T.I.A.S., T.R.G., D.A.L., C.L.R.), University of Bristol, United Kingdom.
Siri E HåbergCentre for Fertility and Health (M.C.M., S.E.H.), Norwegian Institute of Public Health, Oslo.
Wenche NystadDivision of Mental and Physical Health (C.M.P., W.N.), Norwegian Institute of Public Health, Oslo.
Ellen A NohrResearch Unit of Gynaecology and Obstetrics, Department of Clinical Research, University of Southern Denmark, Odense (E.A.N.).
Anne P StarlingDepartment of Epidemiology (A.P.S., I.V.Y., D.D.), University of Colorado Anschutz Medical Campus, Aurora.
Katerina J KechrisDepartment of Biostatistics and Informatics (W.Z., K.J.K.), University of Colorado Anschutz Medical Campus, Aurora.
Ivana V YangDepartment of Epidemiology (A.P.S., I.V.Y., D.D.), University of Colorado Anschutz Medical Campus, Aurora.
Dawn L DeMeoChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.L.D.).
Augusto A LitonjuaDivision of Pediatric Pulmonary Medicine, University of Rochester Medical Center, NY (A.A.L.).
Andrea BaccarelliLaboratory of Precision Environmental Biosciences, Columbia University Mailman School of Public Health, New York, NY (A.B.).
Emily OkenDepartment of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA (S.L.R.-S., E.O., M.-F.H.).
John W HollowayHuman Development and Health (F.I.R., J.W.H.), Faculty of Medicine University of Southampton, United Kingdom.
Wilfried KarmausDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, TN (W.K.).
Syed H ArshadClinical and Experimental Sciences (J.W.H., S.H.A.), Faculty of Medicine University of Southampton, United Kingdom.
Dana DabeleaDepartment of Epidemiology (A.P.S., I.V.Y., D.D.), University of Colorado Anschutz Medical Campus, Aurora.
Thorkild I A SørensenFrom the MRC Integrative Epidemiology Unit (N.K., G.C.S., A.J.S., K.B., T.G.R., D.L.S.F., A.F., M.C.M., T.I.A.S., T.R.G., D.A.L., C.L.R.), University of Bristol, United Kingdom.
Hannele LaivuoriInstitute for Molecular Medicine Finland, Helsinki Institute of Life Science (H.L.), University of Helsinki, Finland.
Katri RaikkonenDepartment of Psychology and Logopedics, Faculty of Medicine (J.L., K.R.), University of Helsinki, Finland.
Janine F FelixThe Generation R Study Group (F.O.V., V.W.V.J., J.F.F.), Erasmus MC, University Medical Center Rotterdam, the Netherlands.
Stephanie J LondonDivision of Intramural Research, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC (S.E.R., Q.E.H., S.Z., S.J.L.).
Marie-France HivertDepartment of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA (S.L.R.-S., E.O., M.-F.H.).
Tom R GauntFrom the MRC Integrative Epidemiology Unit (N.K., G.C.S., A.J.S., K.B., T.G.R., D.L.S.F., A.F., M.C.M., T.I.A.S., T.R.G., D.A.L., C.L.R.), University of Bristol, United Kingdom.
Debbie A LawlorFrom the MRC Integrative Epidemiology Unit (N.K., G.C.S., A.J.S., K.B., T.G.R., D.L.S.F., A.F., M.C.M., T.I.A.S., T.R.G., D.A.L., C.L.R.), University of Bristol, United Kingdom.
Caroline L ReltonFrom the MRC Integrative Epidemiology Unit (N.K., G.C.S., A.J.S., K.B., T.G.R., D.L.S.F., A.F., M.C.M., T.I.A.S., T.R.G., D.A.L., C.L.R.), University of Bristol, United Kingdom.
University of Bristol · GBUniversity of Colorado Anschutz Medical Campus · USNorwegian Institute of Public Health · NOHarvard University · USUniversity of Helsinki · FIUniversity of Southampton · GBErasmus MC · NLNational Institute of Environmental Health Sciences · USNational Institutes of Health · USColumbia University · USEmory University · USErasmus University Rotterdam · NLMassachusetts General Hospital · USMax Planck Institute of Psychiatry · DENovo Nordisk Foundation · DKUniversity Of Bristol Dental Hospital · GBUniversity of Rochester Medical Center · USUniversity of Southern Denmark · DKUniversity of Tennessee Health Science Center · US
Funding
Prenatal environmental determinants of health in young adulthood: a lifecourse approachR01HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI Marie-France Hivert, Emily Oken · 1998 to 2026
$20.6MGenetic And Environmental Factors In Childhood Respiratory HealthZIAES049019 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONDON, STEPHANIE · 2009 to 2025
$6.8MTransgenerational epigenetic inheritance of allergy in a multigenerational cohortR01AI091905 · NIAID · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI KARMAUS, WILFRIED JJ · 2011 to 2015
$2.7MEndocrine disruptors, epigenetic programming and neonatal outcomesR01ES022934 · NIEHS · UNIVERSITY OF COLORADO DENVER · PI ADGATE, JOHN L., DABELEA, DANA · 2014 to 2017
$2.3MMetabolomic and Epigenomic Mechanisms in Developmental Overnutrition.R01DK103246 · NIDDK · UNIVERSITY OF BRISTOL · PI LAWLOR, DEBORAH ANNE · 2014 to 2018
$2.2MMedical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009Medical Research Council MC_UU_00011/4Medical Research Council MC_UU_00011/5Medical Research Council MC_UU_00011/6Medical Research Council MC_UU_12013/2Medical Research Council MR/S003886/1NIAID NIH HHS R01 AI091905NICHD NIH HHS R01 HD034568NIDDK NIH HHS R01 DK103246NIEHS NIH HHS R01 ES022934
Abstract
Hypertensive disorders of pregnancy (HDP) are associated with low birth weight, shorter gestational age, and increased risk of maternal and offspring cardiovascular diseases later in life. The mechanisms involved are poorly understood, but epigenetic regulation of gene expression may play a part. We performed meta-analyses in the Pregnancy and Childhood Epigenetics Consortium to test the association between either maternal HDP (10 cohorts; n=5242 [cases=476]) or preeclampsia (3 cohorts; n=2219 [cases=135]) and epigenome-wide DNA methylation in cord blood using the Illumina HumanMethylation450 BeadChip. In models adjusted for confounders, and with Bonferroni correction, HDP and preeclampsia were associated with DNA methylation at 43 and 26 CpG sites, respectively. HDP was associated with higher methylation at 27 (63%) of the 43 sites, and across all 43 sites, the mean absolute difference in methylation was between 0.6% and 2.6%. Epigenome-wide associations of HDP with offspring DNA methylation were modestly consistent with the equivalent epigenome-wide associations of preeclampsia with offspring DNA methylation (R
Indexed as
Genome-Wide Association StudyInfant, PrematurePregnancy OutcomeAdultCohort StudiesDNA-Binding ProteinsDNA MethylationEpigenesis, GeneticFemaleFetal BloodGestational AgeHumansHypertension, Pregnancy-InducedInfant, NewbornPregnancyDNA-Binding Proteinscardiovascular diseasesDNA methylationgestational agehypertensionpreeclampsia
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