ArticleThe American journal of psychiatry2019
Evidence for Dissociable Linkage of Dimensions of Psychopathology to Brain Structure in Youths.
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Article in The American journal of psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
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73citing papers in PubMed, 4 pooled it
7.1field-weighted citation impact, top 2% of its field
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Who cites it
73 citing papers in PubMed, 4 syntheses or guidelines pooled it, 117 citations in OpenAlex.
- Identification of a diagnosis-selective neurobiological substrate for bipolar disorder, major depressive disorder, and schizophrenia: a meta-analysis of 57,717 subjects.Psychological medicine · 2026Pooled it
- Common neural dysfunction in psychiatric disorders: Insights from a meta-analysis of resting-state fMRI studies.Translational psychiatry · 2025Pooled it
- The hierarchical taxonomy of psychopathology and the search for neurobiological substrates of mental illness: A systematic review and roadmap for future research.Journal of psychopathology and clinical science · 2024Pooled it
- Neural substrates of motivational dysfunction across neuropsychiatric conditions: Evidence from meta-analysis and lesion network mapping.Clinical psychology review · 2022Pooled it
- Cerebellar Functional Alterations During Executive Functioning Are Associated With General Psychopathology in a Cross-Diagnostic Sample.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Associations of general and specific psychopathology factors by age 35 with dementia after age 50: a Swedish population-based sibling comparison study.Molecular psychiatry · 2026Article
- Neuroanatomical Subtypes of Callous-Unemotional Traits in a Community Sample of Youth.bioRxiv : the preprint server for biology · 2026Article
- The topology of adolescent mental health.medRxiv : the preprint server for health sciences · 2026Article
- Subtypes of adolescent major depressive disorder characterized by divergent information dynamics in sensory-association cortices.Nature communications · 2026Article
- Neurostructural Substrates of Hierarchical Dimensions of Internalizing Symptoms in Youth.Human brain mapping · 2026Article
- Taming dimensionality in big neuroimaging data: Efficient orthonormal projective NMF via stochastic learning and data compression.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Neurostructural Differences Associated With Prodromal Mania Symptoms in Children.Brain and behavior · 2025Review
- The overlapping genetic architecture of psychiatric disorders and cortical brain structure.Nature. Mental health · 2025Article
- Structural Brain Correlates of Multidomain Resilience Among Youth Exposed to Neighborhood Disadvantage.Biological psychiatry global open science · 2025Article
- Prospective Relations between Cortical Thickness and Change in Internalizing Symptoms are Moderated by Chronic Stress Exposure in Adolescents with Depression and Anxiety.Clinical psychological science : a journal of the Association for Psychological Science · 2025Article
- Longitudinal associations between youth prosocial behavior and dimensions of psychopathology.JCPP advances · 2025Article
- Structure-function coupling in network connectivity and associations with negative affectivity in a group of transdiagnostic adolescents.Journal of mood and anxiety disorders · 2025Article
- A longitudinal investigation of the relationship between dimensional psychopathology, gray matter structure, and dementia status in older adulthood.Psychological medicine · 2025Article
- Investigating cross-sectional and longitudinal relationships between brain structure and distinct dimensions of externalizing psychopathology in the ABCD sample.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Brain connectomes in youth at risk for serious mental illness: a longitudinal perspective.Brain imaging and behavior · 2025Article
13 more citing papers are in PubMed but not listed here.
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Authors and funding
20 authors at 1 institution in 1 country.
Antonia N KaczkurkinThe Department of Psychiatry (Kaczkurkin, Moore, Calkins, Cieslak, Rosen, Ciric, Xia, Cui, Sharma, Wolf, Ruparel, Roalf, R.C. Gur, R.E. Gur, Satterthwaite) and the Department of Radiology (Sotiras, R.C. Gur, Davatzikos, R.E. Gur), Perelman School of Medicine, University of Pennsylvania, Philadelphia; the Department of Psychiatry, Lewis Katz School of Medicine, Temple University, Philadelphia (Park); the Department of Radiology, Washington University, St. Louis (Sotiras); the Emotion and Development Branch, Intramural Research Program, NIMH, Bethesda, Md. (Pine); the Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia (Shinohara); and the Philadelphia Veterans Administration Medical Center, Philadelphia (R.C. Gur).
Sophia Seonyeong ParkThe Department of Psychiatry (Kaczkurkin, Moore, Calkins, Cieslak, Rosen, Ciric, Xia, Cui, Sharma, Wolf, Ruparel, Roalf, R.C. Gur, R.E. Gur, Satterthwaite) and the Department of Radiology (Sotiras, R.C. Gur, Davatzikos, R.E. Gur), Perelman School of Medicine, University of Pennsylvania, Philadelphia; the Department of Psychiatry, Lewis Katz School of Medicine, Temple University, Philadelphia (Park); the Department of Radiology, Washington University, St. Louis (Sotiras); the Emotion and Development Branch, Intramural Research Program, NIMH, Bethesda, Md. (Pine); the Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia (Shinohara); and the Philadelphia Veterans Administration Medical Center, Philadelphia (R.C. Gur).
Aristeidis SotirasThe Department of Psychiatry (Kaczkurkin, Moore, Calkins, Cieslak, Rosen, Ciric, Xia, Cui, Sharma, Wolf, Ruparel, Roalf, R.C. Gur, R.E. Gur, Satterthwaite) and the Department of Radiology (Sotiras, R.C. Gur, Davatzikos, R.E. Gur), Perelman School of Medicine, University of Pennsylvania, Philadelphia; the Department of Psychiatry, Lewis Katz School of Medicine, Temple University, Philadelphia (Park); the Department of Radiology, Washington University, St. Louis (Sotiras); the Emotion and Development Branch, Intramural Research Program, NIMH, Bethesda, Md. (Pine); the Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia (Shinohara); and the Philadelphia Veterans Administration Medical Center, Philadelphia (R.C. Gur).
Tyler M MooreThe Department of Psychiatry (Kaczkurkin, Moore, Calkins, Cieslak, Rosen, Ciric, Xia, Cui, Sharma, Wolf, Ruparel, Roalf, R.C. Gur, R.E. Gur, Satterthwaite) and the Department of Radiology (Sotiras, R.C. Gur, Davatzikos, R.E. Gur), Perelman School of Medicine, University of Pennsylvania, Philadelphia; the Department of Psychiatry, Lewis Katz School of Medicine, Temple University, Philadelphia (Park); the Department of Radiology, Washington University, St. Louis (Sotiras); the Emotion and Development Branch, Intramural Research Program, NIMH, Bethesda, Md. (Pine); the Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia (Shinohara); and the Philadelphia Veterans Administration Medical Center, Philadelphia (R.C. Gur).
Monica E CalkinsThe Department of Psychiatry (Kaczkurkin, Moore, Calkins, Cieslak, Rosen, Ciric, Xia, Cui, Sharma, Wolf, Ruparel, Roalf, R.C. Gur, R.E. Gur, Satterthwaite) and the Department of Radiology (Sotiras, R.C. Gur, Davatzikos, R.E. Gur), Perelman School of Medicine, University of Pennsylvania, Philadelphia; the Department of Psychiatry, Lewis Katz School of Medicine, Temple University, Philadelphia (Park); the Department of Radiology, Washington University, St. Louis (Sotiras); the Emotion and Development Branch, Intramural Research Program, NIMH, Bethesda, Md. (Pine); the Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia (Shinohara); and the Philadelphia Veterans Administration Medical Center, Philadelphia (R.C. Gur).
Matthew CieslakThe Department of Psychiatry (Kaczkurkin, Moore, Calkins, Cieslak, Rosen, Ciric, Xia, Cui, Sharma, Wolf, Ruparel, Roalf, R.C. Gur, R.E. Gur, Satterthwaite) and the Department of Radiology (Sotiras, R.C. Gur, Davatzikos, R.E. Gur), Perelman School of Medicine, University of Pennsylvania, Philadelphia; the Department of Psychiatry, Lewis Katz School of Medicine, Temple University, Philadelphia (Park); the Department of Radiology, Washington University, St. Louis (Sotiras); the Emotion and Development Branch, Intramural Research Program, NIMH, Bethesda, Md. (Pine); the Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia (Shinohara); and the Philadelphia Veterans Administration Medical Center, Philadelphia (R.C. Gur).
Adon F G RosenThe Department of Psychiatry (Kaczkurkin, Moore, Calkins, Cieslak, Rosen, Ciric, Xia, Cui, Sharma, Wolf, Ruparel, Roalf, R.C. Gur, R.E. Gur, Satterthwaite) and the Department of Radiology (Sotiras, R.C. Gur, Davatzikos, R.E. Gur), Perelman School of Medicine, University of Pennsylvania, Philadelphia; the Department of Psychiatry, Lewis Katz School of Medicine, Temple University, Philadelphia (Park); the Department of Radiology, Washington University, St. Louis (Sotiras); the Emotion and Development Branch, Intramural Research Program, NIMH, Bethesda, Md. (Pine); the Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia (Shinohara); and the Philadelphia Veterans Administration Medical Center, Philadelphia (R.C. Gur).
Rastko CiricThe Department of Psychiatry (Kaczkurkin, Moore, Calkins, Cieslak, Rosen, Ciric, Xia, Cui, Sharma, Wolf, Ruparel, Roalf, R.C. Gur, R.E. Gur, Satterthwaite) and the Department of Radiology (Sotiras, R.C. Gur, Davatzikos, R.E. Gur), Perelman School of Medicine, University of Pennsylvania, Philadelphia; the Department of Psychiatry, Lewis Katz School of Medicine, Temple University, Philadelphia (Park); the Department of Radiology, Washington University, St. Louis (Sotiras); the Emotion and Development Branch, Intramural Research Program, NIMH, Bethesda, Md. (Pine); the Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia (Shinohara); and the Philadelphia Veterans Administration Medical Center, Philadelphia (R.C. Gur).
Cedric Huchuan XiaThe Department of Psychiatry (Kaczkurkin, Moore, Calkins, Cieslak, Rosen, Ciric, Xia, Cui, Sharma, Wolf, Ruparel, Roalf, R.C. Gur, R.E. Gur, Satterthwaite) and the Department of Radiology (Sotiras, R.C. Gur, Davatzikos, R.E. Gur), Perelman School of Medicine, University of Pennsylvania, Philadelphia; the Department of Psychiatry, Lewis Katz School of Medicine, Temple University, Philadelphia (Park); the Department of Radiology, Washington University, St. Louis (Sotiras); the Emotion and Development Branch, Intramural Research Program, NIMH, Bethesda, Md. (Pine); the Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia (Shinohara); and the Philadelphia Veterans Administration Medical Center, Philadelphia (R.C. Gur).
Zaixu CuiThe Department of Psychiatry (Kaczkurkin, Moore, Calkins, Cieslak, Rosen, Ciric, Xia, Cui, Sharma, Wolf, Ruparel, Roalf, R.C. Gur, R.E. Gur, Satterthwaite) and the Department of Radiology (Sotiras, R.C. Gur, Davatzikos, R.E. Gur), Perelman School of Medicine, University of Pennsylvania, Philadelphia; the Department of Psychiatry, Lewis Katz School of Medicine, Temple University, Philadelphia (Park); the Department of Radiology, Washington University, St. Louis (Sotiras); the Emotion and Development Branch, Intramural Research Program, NIMH, Bethesda, Md. (Pine); the Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia (Shinohara); and the Philadelphia Veterans Administration Medical Center, Philadelphia (R.C. Gur).
Anup SharmaThe Department of Psychiatry (Kaczkurkin, Moore, Calkins, Cieslak, Rosen, Ciric, Xia, Cui, Sharma, Wolf, Ruparel, Roalf, R.C. Gur, R.E. Gur, Satterthwaite) and the Department of Radiology (Sotiras, R.C. Gur, Davatzikos, R.E. Gur), Perelman School of Medicine, University of Pennsylvania, Philadelphia; the Department of Psychiatry, Lewis Katz School of Medicine, Temple University, Philadelphia (Park); the Department of Radiology, Washington University, St. Louis (Sotiras); the Emotion and Development Branch, Intramural Research Program, NIMH, Bethesda, Md. (Pine); the Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia (Shinohara); and the Philadelphia Veterans Administration Medical Center, Philadelphia (R.C. Gur).
Daniel H WolfThe Department of Psychiatry (Kaczkurkin, Moore, Calkins, Cieslak, Rosen, Ciric, Xia, Cui, Sharma, Wolf, Ruparel, Roalf, R.C. Gur, R.E. Gur, Satterthwaite) and the Department of Radiology (Sotiras, R.C. Gur, Davatzikos, R.E. Gur), Perelman School of Medicine, University of Pennsylvania, Philadelphia; the Department of Psychiatry, Lewis Katz School of Medicine, Temple University, Philadelphia (Park); the Department of Radiology, Washington University, St. Louis (Sotiras); the Emotion and Development Branch, Intramural Research Program, NIMH, Bethesda, Md. (Pine); the Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia (Shinohara); and the Philadelphia Veterans Administration Medical Center, Philadelphia (R.C. Gur).
Kosha RuparelThe Department of Psychiatry (Kaczkurkin, Moore, Calkins, Cieslak, Rosen, Ciric, Xia, Cui, Sharma, Wolf, Ruparel, Roalf, R.C. Gur, R.E. Gur, Satterthwaite) and the Department of Radiology (Sotiras, R.C. Gur, Davatzikos, R.E. Gur), Perelman School of Medicine, University of Pennsylvania, Philadelphia; the Department of Psychiatry, Lewis Katz School of Medicine, Temple University, Philadelphia (Park); the Department of Radiology, Washington University, St. Louis (Sotiras); the Emotion and Development Branch, Intramural Research Program, NIMH, Bethesda, Md. (Pine); the Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia (Shinohara); and the Philadelphia Veterans Administration Medical Center, Philadelphia (R.C. Gur).
Daniel S PineThe Department of Psychiatry (Kaczkurkin, Moore, Calkins, Cieslak, Rosen, Ciric, Xia, Cui, Sharma, Wolf, Ruparel, Roalf, R.C. Gur, R.E. Gur, Satterthwaite) and the Department of Radiology (Sotiras, R.C. Gur, Davatzikos, R.E. Gur), Perelman School of Medicine, University of Pennsylvania, Philadelphia; the Department of Psychiatry, Lewis Katz School of Medicine, Temple University, Philadelphia (Park); the Department of Radiology, Washington University, St. Louis (Sotiras); the Emotion and Development Branch, Intramural Research Program, NIMH, Bethesda, Md. (Pine); the Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia (Shinohara); and the Philadelphia Veterans Administration Medical Center, Philadelphia (R.C. Gur).
Russell T ShinoharaThe Department of Psychiatry (Kaczkurkin, Moore, Calkins, Cieslak, Rosen, Ciric, Xia, Cui, Sharma, Wolf, Ruparel, Roalf, R.C. Gur, R.E. Gur, Satterthwaite) and the Department of Radiology (Sotiras, R.C. Gur, Davatzikos, R.E. Gur), Perelman School of Medicine, University of Pennsylvania, Philadelphia; the Department of Psychiatry, Lewis Katz School of Medicine, Temple University, Philadelphia (Park); the Department of Radiology, Washington University, St. Louis (Sotiras); the Emotion and Development Branch, Intramural Research Program, NIMH, Bethesda, Md. (Pine); the Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia (Shinohara); and the Philadelphia Veterans Administration Medical Center, Philadelphia (R.C. Gur).
David R RoalfThe Department of Psychiatry (Kaczkurkin, Moore, Calkins, Cieslak, Rosen, Ciric, Xia, Cui, Sharma, Wolf, Ruparel, Roalf, R.C. Gur, R.E. Gur, Satterthwaite) and the Department of Radiology (Sotiras, R.C. Gur, Davatzikos, R.E. Gur), Perelman School of Medicine, University of Pennsylvania, Philadelphia; the Department of Psychiatry, Lewis Katz School of Medicine, Temple University, Philadelphia (Park); the Department of Radiology, Washington University, St. Louis (Sotiras); the Emotion and Development Branch, Intramural Research Program, NIMH, Bethesda, Md. (Pine); the Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia (Shinohara); and the Philadelphia Veterans Administration Medical Center, Philadelphia (R.C. Gur).
Ruben C GurThe Department of Psychiatry (Kaczkurkin, Moore, Calkins, Cieslak, Rosen, Ciric, Xia, Cui, Sharma, Wolf, Ruparel, Roalf, R.C. Gur, R.E. Gur, Satterthwaite) and the Department of Radiology (Sotiras, R.C. Gur, Davatzikos, R.E. Gur), Perelman School of Medicine, University of Pennsylvania, Philadelphia; the Department of Psychiatry, Lewis Katz School of Medicine, Temple University, Philadelphia (Park); the Department of Radiology, Washington University, St. Louis (Sotiras); the Emotion and Development Branch, Intramural Research Program, NIMH, Bethesda, Md. (Pine); the Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia (Shinohara); and the Philadelphia Veterans Administration Medical Center, Philadelphia (R.C. Gur).
Christos DavatzikosThe Department of Psychiatry (Kaczkurkin, Moore, Calkins, Cieslak, Rosen, Ciric, Xia, Cui, Sharma, Wolf, Ruparel, Roalf, R.C. Gur, R.E. Gur, Satterthwaite) and the Department of Radiology (Sotiras, R.C. Gur, Davatzikos, R.E. Gur), Perelman School of Medicine, University of Pennsylvania, Philadelphia; the Department of Psychiatry, Lewis Katz School of Medicine, Temple University, Philadelphia (Park); the Department of Radiology, Washington University, St. Louis (Sotiras); the Emotion and Development Branch, Intramural Research Program, NIMH, Bethesda, Md. (Pine); the Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia (Shinohara); and the Philadelphia Veterans Administration Medical Center, Philadelphia (R.C. Gur).
Raquel E GurThe Department of Psychiatry (Kaczkurkin, Moore, Calkins, Cieslak, Rosen, Ciric, Xia, Cui, Sharma, Wolf, Ruparel, Roalf, R.C. Gur, R.E. Gur, Satterthwaite) and the Department of Radiology (Sotiras, R.C. Gur, Davatzikos, R.E. Gur), Perelman School of Medicine, University of Pennsylvania, Philadelphia; the Department of Psychiatry, Lewis Katz School of Medicine, Temple University, Philadelphia (Park); the Department of Radiology, Washington University, St. Louis (Sotiras); the Emotion and Development Branch, Intramural Research Program, NIMH, Bethesda, Md. (Pine); the Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia (Shinohara); and the Philadelphia Veterans Administration Medical Center, Philadelphia (R.C. Gur).
Theodore D SatterthwaiteThe Department of Psychiatry (Kaczkurkin, Moore, Calkins, Cieslak, Rosen, Ciric, Xia, Cui, Sharma, Wolf, Ruparel, Roalf, R.C. Gur, R.E. Gur, Satterthwaite) and the Department of Radiology (Sotiras, R.C. Gur, Davatzikos, R.E. Gur), Perelman School of Medicine, University of Pennsylvania, Philadelphia; the Department of Psychiatry, Lewis Katz School of Medicine, Temple University, Philadelphia (Park); the Department of Radiology, Washington University, St. Louis (Sotiras); the Emotion and Development Branch, Intramural Research Program, NIMH, Bethesda, Md. (Pine); the Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia (Shinohara); and the Philadelphia Veterans Administration Medical Center, Philadelphia (R.C. Gur).
Umma University · KE
Funding
fMRI Studies Of Pediatric Mood And Anxiety DisordersZIAMH002781 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2009 to 2025
$41.5MNeurodevelopmental Genomics: Trajectories of Complex PhenotypesRC2MH089983 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GUR, RAQUEL E · 2009 to 2011
$14.3M2/2 Neurodevelopmental Genomics: Trajectories of Complex PhenotypesRC2MH089924 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI HAKONARSON, HAKON · 2009 to 2011
$10.7MLongitudinal Mapping of Network Development Underlying Executive Dysfunction in AdolescenceR01MH113550 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Danielle Smith Bassett, Theodore Satterthwaite · 2018 to 2026
$6.9MInter-modal Coupling Image AnalyticsR01MH112847 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Theodore Satterthwaite, Russell Takeshi Shinohara · 2017 to 2026
$5.9MMapping Heterogeneity of Neuroanatomical Imaging Signatures of Psychosis via Pattern AnalysisR01MH112070 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS · 2017 to 2020
$2.7MLongitudinal multi-modal neuroimaging of irritability in youthR01MH107703 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI SATTERTHWAITE, THEODORE · 2015 to 2018
$2.6MVirtual Resection to Treat EpilepsyR01NS099348 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI BASSETT, DANIELLE SMITH, LITT, BRIAN · 2016 to 2019
$2.3MTraining in Sex and Gender Differences Research to Improve Women's HealthK12HD085848 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI OQUENDO, MARIA A · 2015 to 2019
$2.2MBiomedical Image Computing and Informatics ClusterS10OD023495 · OD · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS · 2017 to 2017
$1.9MStatistical methods for large and complex databases of ultra-high-dimensionalR01NS085211 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI SHINOHARA, RUSSELL TAKESHI · 2013 to 2017
$1.8MMultimodal brain maturation indices modulating psychopathology and neurocognitionR01MH107235 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GUR, RUBEN C. · 2015 to 2017
$1.5MNICHD NIH HHS K12 HD085848NIH HHS S10 OD023495NIMH NIH HHS K99 MH117274NIMH NIH HHS R00 MH117274NIMH NIH HHS R01 MH107235NIMH NIH HHS R01 MH107703NIMH NIH HHS R01 MH112070NIMH NIH HHS R01 MH112847NIMH NIH HHS R01 MH113550NIMH NIH HHS RC2 MH089924NIMH NIH HHS RC2 MH089983NINDS NIH HHS R01 NS085211NINDS NIH HHS R01 NS099348
Abstract
objectiveHigh comorbidity among psychiatric disorders suggests that they may share underlying neurobiological deficits. Abnormalities in cortical thickness and volume have been demonstrated in clinical samples of adults, but less is known when these structural differences emerge in youths. The purpose of this study was to examine the association between dimensions of psychopathology and brain structure.
methodsThe authors studied 1,394 youths who underwent brain imaging as part of the Philadelphia Neurodevelopmental Cohort. Dimensions of psychopathology were constructed using a bifactor model of symptoms. Cortical thickness and volume were quantified using high-resolution 3-T MRI. Structural covariance networks were derived using nonnegative matrix factorization and analyzed using generalized additive models with penalized splines to capture both linear and nonlinear age-related effects.
resultsFear symptoms were associated with reduced cortical thickness in most networks, and overall psychopathology was associated with globally reduced gray matter volume across all networks. Structural covariance networks predicted psychopathology symptoms above and beyond demographic characteristics and cognitive performance.
conclusionsThe results suggest a dissociable relationship whereby fear is most strongly linked to reduced cortical thickness and overall psychopathology is most strongly linked to global reductions in gray matter volume. Such results have implications for understanding how abnormalities of brain development may be associated with divergent dimensions of psychopathology.
Indexed as
AdolescentAtrophyCerebral CortexChildCognitionFearFemaleGray MatterHumansMagnetic Resonance ImagingMaleMental DisordersNeural PathwaysNeuropsychological TestsPsychopathologyAdolescentsBrainChild PsychiatryCortical ThicknessDevelopmentMRI
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