Evidence map›Paper›PMID 31230425›Full record

ArticleJournal of biomedical optics2019

Experimental investigation of parameters influencing plasmonic nanoparticle-mediated bubble generation with nanosecond laser pulses.

Andrew M Fales, William C Vogt, Keith A Wear, T Joshua Pfefer, Ilko K Ilev

Abstract read
In one paragraph

Article in Journal of biomedical optics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andrew M FalesU.S. Food and Drug Administration, Office of Science and Engineering Laboratories, Center for Device, United States.
William C VogtU.S. Food and Drug Administration, Office of Science and Engineering Laboratories, Center for Device, United States.
Keith A WearU.S. Food and Drug Administration, Office of Science and Engineering Laboratories, Center for Device, United States.
T Joshua PfeferU.S. Food and Drug Administration, Office of Science and Engineering Laboratories, Center for Device, United States.
Ilko K IlevU.S. Food and Drug Administration, Office of Science and Engineering Laboratories, Center for Device, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plasmonic nanoparticles (PNPs) continue to see increasing use in biophotonics for a variety of applications, including cancer detection and treatment. Several PNP-based approaches involve the generation of highly transient nanobubbles due to pulsed laser-induced vaporization and cavitation. While much effort has been devoted to elucidating the mechanisms behind bubble generation with spherical gold nano particles, the effects of particle shape on bubble generation thresholds are not well understood, especially in the nanosecond pulse regime. Our study aims to compare the bubble generation thresholds of gold nanospheres, gold nanorods, and silica-core gold nanoshells with different sizes, resonances, and surface coatings. Bubble generation is detected using a multimodality microscopy platform for simultaneous, nanosecond resolution pump-probe imaging, integrated scattering response, and acoustic transient detection. Nanoshells and large (40-nm width) nanorods were found to have the lowest thresholds for bubble generation, and in some cases they generated bubbles at radiant exposures below standard laser safety limits for skin exposure. This has important implications for both safety and performance of techniques employing pulsed lasers and PNPs.

Indexed as

AcousticsGoldLogistic ModelsMaterials TestingMetal NanoparticlesNanoshellsNanostructuresScattering, RadiationSurface Plasmon ResonanceGoldnanobubblenanorodnanosecondnanoshellplasmonic nanoparticlepulsed laser

Identifiers

PMID31230425
PMCPMC6977022

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.