Evidence map›Paper›PMID 31230416›Full record

ArticleThe FEBS journal2019

Adrenoceptor-related decrease in serum triglycerides is independent of PPARα activation.

Maria Konstandi, Kyriakos E Kypreos, Tsutomu Matsubara, Eva Xepapadaki, Yatrik M Shah, Kristopher Krausz, Christina E Andriopoulou, Aristeidis Kofinas, Frank J Gonzalez

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The FEBS journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Hydroxylation markedly alters how the polychlorinated biphenyl (PCB) congener, PCB52, affects gene expression in human preadipocytes.Toxicology in vitro : an international journal published in association with BIBRA · 2023
    Article
  3. Review
  4. Article
  5. Targeting Adrenergic Receptors in Metabolic Therapies for Heart Failure.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Maria KonstandiDepartment of Pharmacology, Faculty of Medicine, University of Ioannina, Greece.
Kyriakos E KypreosDepartment of Pharmacology, Faculty of Medicine, University of Patras, Rio, Greece.
Tsutomu MatsubaraLaboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-1100-1052
Eva XepapadakiDepartment of Pharmacology, Faculty of Medicine, University of Patras, Rio, Greece.
Yatrik M ShahLaboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Kristopher KrauszLaboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Christina E AndriopoulouDepartment of Pharmacology, Faculty of Medicine, University of Ioannina, Greece.
Aristeidis KofinasDepartment of Pharmacology, Faculty of Medicine, University of Ioannina, Greece.
Frank J GonzalezLaboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
National Institutes of Health · USUniversity of Ioannina · GRUniversity of Patras · GR

Funding

Xenobiotic receptorsZIABC005562 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GONZALEZ, FRANK J · 2009 to 2025
$26.9M
Intramural NIH HHS ZIA BC005562National Strategic Reference Framework NSRF 2007-2013 346985/80753
6 · The paper itself

Abstract

Adrenoceptor (AR)-linked pathways belong to the major components of the stress response system and are associated with the pathophysiology of diseases within the spectrum of metabolic syndrome. In this study, the role of adrenoceptor stimulation in serum triglyceride (TG) regulation in mice was investigated. For this purpose, α

Indexed as

Adipose Tissue, WhiteAdrenergic alpha-1 Receptor AgonistsAnimalsCarrier ProteinsDiacylglycerol O-AcyltransferaseForkhead Box Protein O1Gene Expression RegulationInsulinIsoproterenolLiverMiceNuclear Receptor Subfamily 4, Group A, Member 1PhenylephrinePhosphatidylinositol 3-KinasesPPAR alphaProto-Oncogene Proteins c-aktAdrenergic alpha-1 Receptor AgonistsCarrier ProteinsDgat1 protein, mouseDiacylglycerol O-AcyltransferaseForkhead Box Protein O1Foxo1 protein, mouseInsulinIsoproterenolmicrosomal triglyceride transfer proteinNr4a1 protein, mouseNuclear Receptor Subfamily 4, Group A, Member 1PhenylephrinePhosphatidylinositol 3-KinasesPPAR alphaProto-Oncogene Proteins c-aktReceptors, Adrenergic, alpha-1Receptors, Adrenergic, beta-1Receptors, Adrenergic, beta-2Sterol EsteraseTriglyceridesadrenergic receptorshypertriglyceridemiaPPARαtriglyceridesTRLs

Identifiers

PMID31230416
PMCPMC6829030
OpenAlexW2950692383

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.