Evidence map›Paper›PMID 31230217›Full record

ArticleMetabolic brain disease2019

The effect of hyperglycinemic treatment in captive-bred Vervet monkeys (Chlorocebus aethiops).

Zandisiwe E Magwebu, Mikateko Mazinu, Sahar Abdul-Rasool, Chesa G Chauke

Abstract read
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In one paragraph

Article in Metabolic brain disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Zandisiwe E MagwebuPrimate Unit and Delft Animal Centre, South African Medical Research Council, P.O Box 19070, Tygerberg, Cape Town, 7505, South Africa. zandisiwe.magwebu@mrc.ac.za.ORCID 0000-0003-4861-6018
Mikateko MazinuPrimate Unit and Delft Animal Centre, South African Medical Research Council, P.O Box 19070, Tygerberg, Cape Town, 7505, South Africa.
Sahar Abdul-RasoolMedical Bioscience Department, University of the Western Cape, Belville, South Africa.
Chesa G ChaukePrimate Unit and Delft Animal Centre, South African Medical Research Council, P.O Box 19070, Tygerberg, Cape Town, 7505, South Africa.
South African Medical Research Council · ZAUniversity of the Western Cape · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nonketotic hyperglycinemia (NKH) is a neuro-metabolic disorder caused by a deficiency in the glycine cleavage system (GCS) and glycine transporter 1 (GlyT1). A case of atypical late onset of NKH has been reported in a colony of captive-bred Vervet monkeys. The purpose of this study was to evaluate the effect of sodium benzoate and dextromethorphan in reducing glycine levels in hyperglycinemic monkeys. Twelve captive-bred Vervet monkeys were assigned into three groups consisting of four animals (control, valproate induced and cataract with spontaneous hyperglycinemia). Valproate was used to elevate glycine levels and the induced group was then treated with sodium benzoate and dextromethorphan together with group three to normalise glycine levels in cerebrospinal fluid (CSF) and plasma. Valproate induction elicited changes in phosphate, alkaline phosphatase and platelet count, however, no significant changes in the glycine levels were observed, and this might be due to the individual variability within the group. The treatment intervention was only obtained in the spontaneous group whereby the glycine levels were normalised in CSF and plasma. Therefore, it can be concluded that sodium benzoate and dextromethorphan treatment was effective and beneficial to the hyperglycinemic group.

Indexed as

AnimalsChlorocebus aethiopsDextromethorphanGlycineHyperglycinemia, NonketoticSodium BenzoateTreatment OutcomeDextromethorphanGlycineSodium BenzoateDextromethorphanGlycineSodium benzoateSpontaneous hyperglycinemiaValproate and Vervet monkey

Identifiers

PMID31230217
OpenAlexW2950402913

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.