ArticleGeroScience2019
Telomere length and cancer mortality in American Indians: the Strong Heart Study.
Article in GeroScience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Tumor-derived extracellular vesicle proteins as new biomarkers and targets in precision oncology.Journal of molecular medicine (Berlin, Germany) · 2024Review
- 17-year follow-up of association between telomere length and all-cause mortality, cardiovascular mortality in individuals with metabolic syndrome: results from the NHANES database prospective cohort study.Diabetology & metabolic syndrome · 2023Article
- Lipidomics profiling of biological aging in American Indians: the Strong Heart Family Study.GeroScience · 2023Article
- The Immunomodulation Potential of Exosomes in Tumor Microenvironment.Journal of immunology research · 2021Review
- Establishment and Validation of the Detection of TERT Promoter Mutations by Human Gliomas U251 Cell Lines.BioMed research international · 2021Article
- Genetically Predicted Telomere Length and Its Relationship With Alzheimer's Disease.Frontiers in genetics · 2021Article
- ALKBH1-8 and FTO: Potential Therapeutic Targets and Prognostic Biomarkers in Lung Adenocarcinoma Pathogenesis.Frontiers in cell and developmental biology · 2021Article
- Exosome-based immunotherapy: a promising approach for cancer treatment.Molecular cancer · 2020Review
- The importance of diversity and outreach in geroscience research: Insights from the Annual Biomedical Research Conference for Minority Students.GeroScience · 2020Article
- Spectrum of Mesenchymal-Epithelial Transition Aberrations and Potential Clinical Implications: Insights From Integrative Pancancer Analysis.Frontiers in oncology · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The objective of this study was to investigate whether leukocyte telomere length (LTL) predicts the risk for cancer mortality among American Indians participating in the Strong Heart Study (1989-1991). Participants (aged 45-74 years) were followed annually until December 2015 to collect information on morbidity/mortality. LTL was measured by qPCR using genomic DNA isolated from peripheral blood. The association between LTL and risk for cancer mortality was examined using a multivariable Cox proportional hazard model, adjusting for age, gender, education, study site, smoking, alcohol use, physical activity, systolic blood pressure, fasting blood glucose, obesity, and low- and high-density lipoprotein. Of 1945 participants (mean age 56.10 ± 8.17 at baseline, 57% women) followed for an average 20.5 years, 220 died of cancer. Results showed that longer LTL at baseline significantly predicts an increased risk of cancer death among females (HR 1.57, 95% CI 1.08-2.30), but not males (HR 0.74, 95% CI 0.49-1.12) (p for interaction 0.009). Specifically, compared with the women with the longest LTL (fourth quartile), those in the third, second, and first quartiles showed 53%, 41%, and 44% reduced risk for cancer death, respectively. The findings highlight the importance of sex-specific analysis in future telomere research.
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Registered trials
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