Evidence map›Paper›PMID 31230145›Full record

Observational studyPsychopharmacology2019

A comparison of regional brain volumes and white matter connectivity in subjects with stimulant induced psychosis versus schizophrenia.

Peter D Alexander, Kristina M Gicas, Alex Cheng, Donna J Lang, Ric M Procyshyn, Alexandra T Vertinsky, William J Panenka, Allen E Thornton, Alexander Rauscher, Jamie Y X Wong and 5 more

Abstract readComparative StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Psychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
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  5. Article
  6. Journal of clinical medicine · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Peter D AlexanderDepartment of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, 2176 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada.
Kristina M GicasDepartment of Psychiatry, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
Alex ChengDepartment of Psychiatry, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
Donna J LangDepartment of Radiology, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
Ric M ProcyshynDepartment of Psychiatry, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
Alexandra T VertinskyDepartment of Radiology, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
William J PanenkaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
Allen E ThorntonDepartment of Psychology, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.
Alexander RauscherDepartment of Radiology, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
Jamie Y X WongDepartment of Psychiatry, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
Tasha ChanDepartment of Psychiatry, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
Andrea A JonesDepartment of Psychiatry, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
F Vila-RodriguezDepartment of Psychiatry, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
William G HonerDepartment of Psychiatry, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
Alasdair M BarrDepartment of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, 2176 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada. al.barr@ubc.ca.
University of British Columbia · CASimon Fraser University · CA

Funding

CIHR 101827/137103
6 · The paper itself

Abstract

rationaleSchizophrenia and stimulant-induced psychosis (SIP) represent two different forms of psychotic disorder, with different etiologies. While many of the symptoms of psychosis are common to both disorders, there have been few direct comparisons between these conditions, especially when controlling for stimulant use in individuals with schizophrenia.

objectivesWe directly compared both psychotic disorders with a comprehensive battery of clinical, neurocognitive and neuroanatomical measures. This included one group with SIP (and concurrent stimulant dependence) and two groups with schizophrenia (either with or without concurrent stimulant dependence).

methodsNinety-six participants were recruited from a marginalized urban population, which included 39 with SIP (and concurrent stimulant dependence), 18 with schizophrenia (without stimulant dependence), and 39 with schizophrenia (with concurrent stimulant dependence). All subjects had extensive clinical and neurocognitive evaluations, complemented with structural MRI including diffusion tensor imaging (DTI) sequences to determine regional brain volumes and white matter connectivity.

resultsBoth positive and negative symptoms were greater in the SZ-dependent group than the other two. Neurocognitive function was broadly similar. The structural brain imaging revealed lateralized changes to the left parietal/temporal lobe, in which regional volumes were smaller in the SZ-dependent than the SZ-non-dependent group. DTI analysis indicated extensive decreases in fractional anisotropy, with parallel increases in radial diffusivity, in the SIP group compared to the SZ-dependent group.

conclusionsThese findings reveal both similarities and differences between SIP and schizophrenia. Furthermore, schizophrenia with concurrent stimulant dependence may be associated with a different clinical and neuroanatomical profile as compared to schizophrenia alone.

Indexed as

AdultBrainBrain MappingCentral Nervous System StimulantsCohort StudiesDiffusion Tensor ImagingFemaleHumansLongitudinal StudiesMaleMiddle AgedPsychoses, Substance-InducedSchizophreniaSchizophrenic PsychologyWhite MatterYoung AdultCentral Nervous System StimulantsCocaineCognitionDependenceDiffusion tensor imagingMethamphetamineMRIPANSSPsychosisSchizophreniaSubstance use

Identifiers

PMID31230145
OpenAlexW2951260381

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.