Evidence map›Paper›PMID 31230130›Full record

ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2019

Green synthesis of copper oxide nanoparticles using sinapic acid: an underpinning step towards antiangiogenic therapy for breast cancer.

Desingh Raj Preeth, Manickaraj Shairam, Natarajan Suganya, Roshandel Hootan, Ravishankar Kartik, Kennepohl Pierre, Chatterjee Suvro, Subramaniyam Rajalakshmi

Abstract read
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In one paragraph

Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.

  1. Application of nanoparticles in breast cancer treatment: a systematic review.Naunyn-Schmiedeberg's archives of pharmacology · 2024
    Pooled it
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  15. Biosynthesis ofACS omega · 2023
    Article
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  19. Sinapic Acid and Sinapate Esters inFrontiers in chemistry · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Desingh Raj Preeth *Chemical Biology and Nanobiotechnology Laboratory, AU-KBC Research Centre, Anna University, MIT Campus, Chromepet, Chennai, 600 044, India.
Manickaraj Shairam *Chemical Biology and Nanobiotechnology Laboratory, AU-KBC Research Centre, Anna University, MIT Campus, Chromepet, Chennai, 600 044, India.
Natarajan SuganyaVascular Biology Laboratory, Department of Biotechnology and AU-KBC Research Centre, Anna University, MIT Campus, Chromepet, Chennai, 600 044, India.
Roshandel HootanDepartment of Chemistry, The University of British Columbia, 2036 Main Hall, Vancouver, BC, V6T 1Z1, Canada.
Ravishankar KartikDepartment of Chemistry, IIT Madras, Chennai, 600 036, India.
Kennepohl PierreDepartment of Chemistry, The University of British Columbia, 2036 Main Hall, Vancouver, BC, V6T 1Z1, Canada.
Chatterjee SuvroVascular Biology Laboratory, Department of Biotechnology and AU-KBC Research Centre, Anna University, MIT Campus, Chromepet, Chennai, 600 044, India.
Subramaniyam RajalakshmiChemical Biology and Nanobiotechnology Laboratory, AU-KBC Research Centre, Anna University, MIT Campus, Chromepet, Chennai, 600 044, India. rajimaniyam@gmail.com.
Anna University, Chennai · INUniversity of British Columbia · CAIndian Institute of Technology Madras · IN

Funding

Science and Engineering Research Board DST/INSPIRE/04/2015/001945
6 · The paper itself

Abstract

Synthesis of copper oxide nanoparticles without any chemical reductant is always a challenging methodology for biological studies. In this study, sinapic acid, a phytochemical, is used for the synthesis of stable copper oxide nanoparticles. The as-synthesized nanoparticles were characterized thoroughly using UV-Visible, IR spectroscopy, Transmission Electron Microscopy (TEM) and X-ray photoelectron spectroscopy (XPS). Nanoparticles collected during different time intervals of synthesis (60,120 and 180 min) were subjected for analysis, where the occurrence of copper oxide nanoparticles with substantial morphology was seen at 180 min. Further, nanoparticles synthesized at 120 and 180 min were studied for their potential biological applications. These copper oxide nanoparticles evinced potential cytotoxic effects on breast cancer cells, MCF7 and MDA-MB231. Supplementarily, it also exhibited anti-angiogenic effect on endothelial cells (EA.hy926), thus confirming its potential to inhibit angiogenesis in cancer.

Indexed as

Breast NeoplasmsCell Line, TumorCopperCoumaric AcidsHumansMCF-7 CellsMetal NanoparticlesMicroscopy, Electron, TransmissionPhotoelectron SpectroscopyReactive Oxygen SpeciesSpectroscopy, Fourier Transform InfraredWound HealingCopperCoumaric Acidscuprous oxideReactive Oxygen Speciessinapinic acidAngiogenesisCopper oxide nanoparticleMCF7 and MDA-MB231Sinapic acidTEM

Identifiers

PMID31230130
OpenAlexW2950093358

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.