Evidence map›Paper›PMID 31230126›Full record

ArticleMikrochimica acta2019

A chemiluminescence resonance energy transfer strategy and its application for detection of platinum ions and cisplatin.

Sheng Cai, Ying Zhou, Jiawei Ye, Ruizhe Chen, Lianli Sun, Jianzhong Lu, Cheulhee Jung, Su Zeng

Abstract read
PubMed Publisher
In one paragraph

Article in Mikrochimica acta, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 12 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Sheng CaiInstitute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Zhejiang University, Hangzhou, 310058, Zhejiang, China.
Ying ZhouSchool of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, China.
Jiawei YeInstitute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Zhejiang University, Hangzhou, 310058, Zhejiang, China.
Ruizhe ChenInstitute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Zhejiang University, Hangzhou, 310058, Zhejiang, China.
Lianli SunInstitute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Zhejiang University, Hangzhou, 310058, Zhejiang, China.
Jianzhong LuSchool of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, China.
Cheulhee JungDivision of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea. damo363@gmail.com.
Su ZengInstitute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Zhejiang University, Hangzhou, 310058, Zhejiang, China. zengsu@zju.edu.cn.
Zhejiang University · CNFudan University · CNKorea University · KR

Funding

National Natural Science Foundation of China 21405136National Natural Science Foundation of China 81673399National Research Foundation of Korea 2018R1C1B6001112Natural Science Foundation of Zhejiang Province LY18H300003the National Key Project of China 2017YFC0908600
6 · The paper itself

Abstract

A novel chemiluminescence resonance energy transfer (CRET) system was developed and combined with a structure-switching aptamer for the highly sensitive detection of platinum. Platinum was chosen as a model analyte to demonstrate the generality of the new CRET system. This aptameric platform consisted of a streptavidin labeled aptamer against platinum and a streptavidin-coated magnetic bead for the selective separation of platinum-bound aptamer. The platinum-aptamer probe contained several guanine (G) bases bound to the 3,4,5-trimethoxyphenyl-glyoxal (TMPG) donor group at the 5' end, a fluorescent acceptor (6-carboxy-2',4,7,7'-tetrachlorofluorescein, TET) at the 3' end, and a streptavidin aptamer sequence in which several base pairs were replaced by the G-G mismatch to induce the platinum-oligonucleotide coordination. The chemiluminescence (CL) generated by TMPG/G bases is transferred to the acceptor (TET). In the presence of platinum, the platinum-aptamer probe was folded such that the G bases at the 5' end and TET at the 3' were in close proximity. The complex was separated using streptavidin-coated magnetic beads by the addition of TMPG to form the TMPG/G bases complex. The ultraweak CL from the TMPG/G bases was strongly enhanced by TET. This novel CRET-based method can be easily performed with high limit of detection (50 ng·mL

Indexed as

AnimalsAptamers, NucleotideCisplatinEnergy TransferFluoresceinsFluorescent DyesGlyoxalGuanineLimit of DetectionLuminescenceLuminescent MeasurementsMagnetic PhenomenaPlatinumRats, Sprague-DawleyStreptavidin6-carboxy-4,7,2',7'-tetrachlorofluoresceinAptamers, NucleotideCisplatinFluoresceinsFluorescent DyesGlyoxalGuaninePlatinumStreptavidinCRETPlatinum aptameric platformPlatinum detectionPlatinum-oligonucleotide coordinationStreptavidin aptamer

Identifiers

PMID31230126
OpenAlexW2950059550

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.