Evidence map›Paper›PMID 31230088›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2019

Early lesion detection with

M Wondergem, B H E Jansen, F M van der Zant, T M van der Sluis, R J J Knol, L W M van Kalmthout, O S Hoekstra, R J A van Moorselaar, D E Oprea-Lager, A N Vis

Open access · hybridAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 5 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 5 syntheses or guidelines pooled it, 70 citations in OpenAlex.

  1. Effect ofFrontiers in medicine · 2024
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. The Diagnostic Role ofFrontiers in oncology · 2021
    Pooled it
  6. [European journal of nuclear medicine and molecular imaging · 2026
    Trial
  7. An intra-patient contemporaneous comparison ofEuropean journal of nuclear medicine and molecular imaging · 2026
    Trial
  8. Radiology · 2022
    Trial
  9. Patterns of disease detection using [European journal of nuclear medicine and molecular imaging · 2021
    Trial
  10. Pelvic lymph-node staging withEuropean journal of nuclear medicine and molecular imaging · 2021
    Trial
  11. Trial
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. [Salvage lymphadenectomy for recurrent prostate cancer].Urologie (Heidelberg, Germany) · 2024
    Review
  18. Article
  19. Review
  20. Changes in Management AfterJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

M WondergemNoordwest Ziekenhuisgroep, Nuclear Medicine, Wilhelminalaan 12, 1815 JD, Alkmaar, the Netherlands.
B H E JansenAmsterdam University Medical Centers, VU University, Urology, De Boelelaan 1117, 1081 HV, Amsterdam, the Netherlands. bh.jansen@vumc.nl.ORCID http://orcid.org/0000-0003-2107-145X
F M van der ZantNoordwest Ziekenhuisgroep, Nuclear Medicine, Wilhelminalaan 12, 1815 JD, Alkmaar, the Netherlands.
T M van der SluisAmsterdam University Medical Centers, VU University, Urology, De Boelelaan 1117, 1081 HV, Amsterdam, the Netherlands.
R J J KnolNoordwest Ziekenhuisgroep, Nuclear Medicine, Wilhelminalaan 12, 1815 JD, Alkmaar, the Netherlands.
L W M van KalmthoutRadiology & Nuclear Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.
O S HoekstraAmsterdam University Medical Centers, VU University, Radiology & Nuclear Medicine, Amsterdam, the Netherlands.
R J A van MoorselaarAmsterdam University Medical Centers, VU University, Urology, De Boelelaan 1117, 1081 HV, Amsterdam, the Netherlands.
D E Oprea-LagerAmsterdam University Medical Centers, VU University, Radiology & Nuclear Medicine, Amsterdam, the Netherlands.
A N VisAmsterdam University Medical Centers, VU University, Urology, De Boelelaan 1117, 1081 HV, Amsterdam, the Netherlands.
Amsterdam University Medical Centers · NLNoordwest Ziekenhuisgroep · NLUniversity Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeProstate-specific membrane antigen (PSMA) PET/CT is increasingly used in patients with biochemically recurrent prostate cancer (BCR), mostly using gallium-68 (

methodsA total of 248 consecutive patients were evaluated and underwent scanning with

resultsIn 214 out of 248 PET/CT scans (86.3%), at least one lesion suggestive of cancer recurrence was detected ('positive scan'). Scan positivity increased with higher PSA values: 17/29 scans (59%) with PSA values <0.5 ng/ml; 20/29 (69%) with PSA 0.5 to <1.0 ng/ml; 35/41 (85%) with PSA 1.0 to <2.0 ng/ml; 69/73 (95%) with PSA 2.0 to <5.0 ng/ml; and 73/76 (96%) with PSA ≥5.0 ng/ml. Interestingly, suspicious lesions outside the prostatic fossa were detected in 39-50% of patients with PSA <1.0 ng/ml after radical prostatectomy (i.e. candidates for salvage radiotherapy).

conclusion

Indexed as

Early Detection of CancerPositron Emission Tomography Computed TomographyAgedHumansLysineMaleProstatic NeoplasmsRecurrenceRetrospective StudiesUrea2-(3-(1-carboxy-5-((6-fluoropyridine-3-carbonyl)amino)pentyl)ureido)pentanedioic acidLysineUrea18F-DCFPyL PET/CTBiochemically recurrentProstate cancerPSMA

Identifiers

PMID31230088
PMCPMC6647179
OpenAlexW2950800146

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.