Evidence map›Paper›PMID 31230019›Full record

Observational studyBMJ open2019

Prostate cancer with bone metastasis in Beijing: an observational study of prevalence, hospital visits and treatment costs using data from an administrative claims database.

Lin Zhuo, Yinchu Cheng, Yuting Pan, Jihong Zong, Wentao Sun, Lin Xu, Montse Soriano-Gabarró, Yi Song, Jian Lu, Siyan Zhan

Abstract readObservational Study
In one paragraph

Observational study in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. ExPeCT: a randomised trial examining the impact of exercise on quality of life in men with metastatic prostate cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Trial
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Imaging signs and the qualitative diagnosis of solitary rib lesions usingQuantitative imaging in medicine and surgery · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. AMPK's double-faced role in advanced stages of prostate cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022
    Review
  14. Article
  15. Article
  16. Factors predicting biochemical response and survival benefits following radioligand therapy with [European journal of nuclear medicine and molecular imaging · 2021
    Review
  17. Observational
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lin ZhuoDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.ORCID 0000-0001-9188-702X
Yinchu ChengDepartment of Pharmacy, Peking University Third Hospital, Beijing, China.
Yuting PanDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Jihong ZongEpidemiology, Bayer U.S. Whippany, New Jersey, USA.
Wentao SunHEOR and Medical Affairs, Bayer Healthcare Co., Ltd., Beijing, China.
Lin XuHEOR and Medical Affairs, Bayer Healthcare Co., Ltd., Beijing, China.
Montse Soriano-GabarróEpidemiology, Bayer AG, Berlin, Germany.
Yi SongPeking University First Hospital, Beijing, China.
Jian LuDepartment of Urology, Peking University Third Hospital, Beijing, China.
Siyan ZhanDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo estimate the prevalence of prostate cancer with bone metastasis in Beijing, and to estimate hospital visits and direct treatment costs among male urban employees with the disease in Beijing.

designCross-sectional observational study. SETTING AND

participantsPatients with prostate cancer and bone metastasis from the Urban Employee Basic Medical Insurance database covering the employed population of Beijing, China, from 2011 to 2014. PRIMARY AND SECONDARY OUTCOME MEASURES: Prevalence, treatment costs and healthcare visits of patients with prostate cancer and bone metastasis.

resultsA total of 1672 individuals were identified as having prostate cancer. Of these, 737 (44.1%) had bone metastasis, and among these, this was already present at the time of initial prostate cancer diagnosis in 27.0% (199/737). Mean age was 74.6 years (SD ±9.1). Prevalence of prostate cancer with bone metastasis increased from 5.3 per 100 000 males in 2011 to 8.3 per 100 000 males in 2014. The total annual health expenditure per patient (in 2014 American dollars) during the study period was $15 772.1 (SD=$16 942.6) ~$18 206.3 (SD=$18 700.2); 88% of these costs were reimbursed by insurance. Medication accounted for around 50% of total healthcare costs. Western drugs accounted for over 80% of medical costs with endocrine therapy being the most commonly prescribed treatment. There was an average 6.7% increase in expenditure related to diagnostical and therapeutical procedures over study years.

conclusionsThe increase in the prevalence of prostate cancer with bone metastasis and associated healthcare costs in China reveals the growing clinical and economical burden of this disease. The high prevalence of bone metastasis among patients with prostate cancer seen in our study suggests that efforts may be needed to improve symptoms awareness and promote early help-seeking behaviour among the Chinese population.

Indexed as

AgedBone NeoplasmsChinaCross-Sectional StudiesDatabases, FactualHealth Care CostsHumansInsurance Claim ReviewMalePrevalenceProstatic Neoplasmsadministrative claims databaseprevalenceprostate cancer with bone metastasistreatment costs

Identifiers

PMID31230019
PMCPMC6597097

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.