Evidence map›Paper›PMID 31229956›Full record

Trial reportArchives of disease in childhood. Fetal and neonatal edition2020

Achieved oxygen saturations and retinopathy of prematurity in extreme preterms.

Marie G Gantz, Waldemar A Carlo, Neil N Finer, Wade Rich, Roger G Faix, Bradley A Yoder, Michele C Walsh, Nancy S Newman, Abbott Laptook, Kurt Schibler and 3 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Archives of disease in childhood. Fetal and neonatal edition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05508308 (Automated Oxygen Control for Preterm Infants On Continuous Positive Airway Pressure), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05508308 nacompletednot on this mapstarted 2022, after this paper: background citation

Automated Oxygen Control for Preterm Infants On Continuous Positive Airway Pressure (CPAP): Phase 1/2 Trial In Southwest Nigeria

TypeinterventionalSponsorMurdoch Childrens Research InstituteRan2022 to 2023Enrolled49ConditionsNeonatal Respiratory Distress Related Conditions, Neonatal Respiratory Failure, Prematurity, Oxygen ToxicityArmsOxyMate, Manual oxygen control
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 27 citations in OpenAlex.

  1. Evolution of oxygen therapy in preterm infants.Archives of disease in childhood. Fetal and neonatal edition · 2026
    Article
  2. Review
  3. Observational
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Oxygen management among infants in neonatal units in sub-Saharan Africa: a cross-sectional survey.Journal of perinatology : official journal of the California Perinatal Association · 2021
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 10 institutions in 1 country.

Marie G GantzSocial, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Institute, Durham, North Carolina, USA.
Waldemar A CarloPediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Neil N FinerDepartment of Paediatrics Neonatology, UCFD Medical Centre, San Diego, California, USA.
Wade RichNeonatology, University of California, San Diego, California, USA.ORCID http://orcid.org/0000-0003-1420-9828
Roger G FaixPediatrics/Neonatology, University of Utah, Salt Lake City, Utah, USA.
Bradley A YoderPediatrics, University of Utah, Salt Lake City, Utah, USA.
Michele C WalshPediatrics, Case Western Reserve University, Cleveland, Ohio, USA.
Nancy S NewmanPediatrics, Case Western Reserve University, Cleveland, Ohio, USA.
Abbott LaptookDepartment of Pediatrics, Women & Infants Hospital, Providence, Rhode Island, USA.
Kurt SchiblerPediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Abhik DasSocial, Statistical and Environmental Sciences Unit, RTI International, Rockville, Maryland, USA.
Rosemary D HigginsCollege of Health and Human Services, George Mason University, Fairfax, Virginia, USA.
SUPPORT Study Group of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Pediatrics and Genetics · USUniversity of Utah · USCincinnati Children's Hospital Medical Center · USGeorge Mason University · USProvidence College · USRTI International · USStatistical and Applied Mathematical Sciences Institute · USUniversity of Alabama at Birmingham · USUniversity of California San Diego Medical Center · USUniversity of California System · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Neonatal Research Network Data Coordinating Center (DCC) 2023-2028U24HD095254 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI Abhik Das · 2018 to 2026
$70.2M
Neonatal Research Network Data Coordinating Center (DCC)U10HD036790 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI DAS, ABHIK · 2008 to 2017
$62.3M
YALE UNIVERSITY CLINICAL AND TRANSLATIONAL SCIENCE AWARD PROGRAMUL1RR024139 · NCRR · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2006 to 2011
$56.8M
Convalescent Plasma to Limit Coronavirus Associated ComplicationsUL1TR003167 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KARP, DANIEL D, MCPHERSON, DAVID D · 2019 to 2023
$45.3M
Stanford Center for Clinical & Translational Education and Research (Spectrum)UL1TR003142 · NCATS · STANFORD UNIVERSITY · PI O'HARA, RUTH M · 2019 to 2023
$45.0M
WORKER PROTECTION AGAINST AIRBORNE INFLUENZA - A PILOT STUDYM01RR007122 · NCRR · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HUNDLEY, WILLIAM GREGORY · 1992 to 2010
$35.2M
UNIVERSITY OF IOWA CTSA FOR PEDIATRIC RESEARCHUL1RR024979 · NCRR · UNIVERSITY OF IOWA · PI ROSENTHAL, GARY E · 2007 to 2011
$31.8M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025008 · NCRR · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2007 to 2011
$29.0M
Stanford Center for Clinical and Translational Education and Research (SCCTER)UL1UL1RR025744 · NCRR · STANFORD UNIVERSITY · PI GREENBERG, HARRY BERNARD · 2008 to 2011
$22.4M
VITAMIN K DEFICIENCY IN CHOLESTATIC LIVER DISEASEM01RR008084 · NCRR · CINCINNATI CHILDRENS HOSP MED CTR · PI HEUBI, JAMES E. · 1994 to 2009
$20.6M
NICHD Cooperative Multicenter Neonatal Research NetworkU10HD021385 · NICHD · WAYNE STATE UNIVERSITY · PI SHANKARAN, SEETHA · 1991 to 2015
$8.7M
NCATS NIH HHS UL1 TR001863NCATS NIH HHS UL1 TR003142NCATS NIH HHS UL1 TR003167NCRR NIH HHS M01 RR007122NCRR NIH HHS M01 RR008084NCRR NIH HHS M01 RR016587NCRR NIH HHS UL1 RR024139NCRR NIH HHS UL1 RR024979NCRR NIH HHS UL1 RR025008NCRR NIH HHS UL1 RR025744NICHD NIH HHS U10 HD021364NICHD NIH HHS U10 HD021373NICHD NIH HHS U10 HD021385NICHD NIH HHS U10 HD021397NICHD NIH HHS U10 HD027851NICHD NIH HHS U10 HD027853NICHD NIH HHS U10 HD027856NICHD NIH HHS U10 HD027871NICHD NIH HHS U10 HD027880NICHD NIH HHS U10 HD027904NICHD NIH HHS U10 HD034216NICHD NIH HHS U10 HD036790NICHD NIH HHS U10 HD040461NICHD NIH HHS U10 HD040492NICHD NIH HHS U10 HD040498NICHD NIH HHS U10 HD040521NICHD NIH HHS U10 HD040689NICHD NIH HHS U10 HD053089NICHD NIH HHS U10 HD053109NICHD NIH HHS U10 HD053119NICHD NIH HHS U10 HD053124NICHD NIH HHS U24 HD095254NICHD NIH HHS UG1 HD027853NICHD NIH HHS UG1 HD027880NICHD NIH HHS UG1 HD027904NICHD NIH HHS UG1 HD034216NICHD NIH HHS UG1 HD087226NICHD NIH HHS UG1 HD087229
6 · The paper itself

Abstract

objectiveTo identify achieved oxygen saturations (SpO

designThis is a secondary analysis of the Surfactant Positive Airway Pressure and Pulse Oximetry Trial (SUPPORT)randomised controlled trial. SpO

setting20 centres of the PATIENTS: 984 surviving infants of 24-27 weeks' gestational age born in 2005-2009.

interventionsSUPPORT targeted SpO

main outcome measuresSevere ROP defined as threshold ROP, ophthalmological surgery or bevacizumab treatment.

resultsThere were statistically significant interactions between duration of oxygen supplementation and percentage of time in certain achieved saturation ranges. Specifically, for infants who spent at least 2 weeks on oxygen in postnatal weeks 1-5, a higher percentage of time at 91%-96% SpO

conclusionsAmong extremely preterm survivors to discharge, the association between SpO

Indexed as

Infant, Extremely PrematureBirth WeightDose-Response Relationship, DrugFemaleGestational AgeHumansInfant, NewbornLogistic ModelsMaleOximetryOxygenOxygen Inhalation TherapyRetinopathy of PrematurityRisk FactorsSeverity of Illness IndexOxygenneonatologyophthalmologyrespiratory

Identifiers

PMID31229956
PMCPMC6925651
OpenAlexW2952332713

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.