ArticleEuropean journal of cancer (Oxford, England : 1990)2019
Long-term excess risk of breast cancer after a single breast density measurement.
Article in European journal of cancer (Oxford, England : 1990), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Interobserver variability of recall decisions between mammography readers in the English NHS breast screening programme: A comparison of interobserver variability measures.European journal of radiology · 2026Article
- Breast Cancer in Asia: Incidence, Mortality, Early Detection, Mammography Programs, and Risk-Based Screening Initiatives.Cancers · 2022Review
- Breast cancer risk stratification for mammographic screening: A nation-wide screening cohort of 24,431 women in Singapore.Cancer medicine · 2021Article
- In utero DDT exposure and breast density before age 50.Reproductive toxicology (Elmsford, N.Y.) · 2020Article
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
Abstract
aimBreast density is a risk factor for breast cancer. As density changes across a woman's life span, we studied for how long a single density measurement taken in (post-)menopausal women remains informative.
methodsWe used data from Singaporean women who underwent a single mammography screen at age 50-64 years. For each case with breast cancer diagnosed at screening or in the subsequent 10 years, whether screen detected or diagnosed following symptoms, two age-matched controls were selected. We studied the excess risk of breast cancer, calculated as an odds ratio (OR) with conditional logistic regression and adjusted for body mass index, associated with 26-50% and with 51-100% density compared with ≤25% density by time since screening.
resultsIn total, 490 women had breast cancer, of which 361 were diagnosed because of symptoms after screening. Women with 51-100% breast density had an excess risk of breast cancer that did not seem to attenuate with time. In 1-3 years after screening, the OR was 2.22 (95% confidence interval [CI]: 1.07-4.61); in 4-6 years after screening, the OR was 4.09 (95% CI: 2.21-7.58), and in 7-10 years after screening, the OR was 5.35 (95% CI: 2.57-11.15). Excess risk with a stable OR of about 2 was also observed for women with 26-50% breast density. These patterns were robust when the analyses were limited to post-menopausal women, non-users of hormonal replacement therapy and after stratification by age at density measurement.
conclusionA single breast density measurement identifies women with an excess risk of breast cancer during at least the subsequent 10 years.
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