Evidence map›Paper›PMID 31229841›Full record

ArticleRedox biology2019

PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation.

Qisheng Lin, Shu Li, Na Jiang, Xinghua Shao, Minfang Zhang, Haijiao Jin, Zhen Zhang, Jianxiao Shen, Yijun Zhou, Wenyan Zhou and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 366 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
366citing papers in PubMed, 1 pooled it
32.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

366 citing papers in PubMed, 1 synthesis or guideline pooled it, 589 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Selective autophagy in kidney health and disease.Nature reviews. Nephrology · 2026
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

306 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Qisheng LinDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China.
Shu LiDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China.
Na JiangDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China.
Xinghua ShaoDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China.
Minfang ZhangDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China.
Haijiao JinDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China.
Zhen ZhangDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China.
Jianxiao ShenDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China.
Yijun ZhouDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China.
Wenyan ZhouDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China.
Leyi GuDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China.
Renhua LuDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China.
Zhaohui NiDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China. Electronic address: profnizh@126.com.
Renji Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Contrast-induced acute kidney injury (CI-AKI) occurs in more than 30% of patients after intravenous iodinated contrast media and causes serious complications, including renal failure and mortality. Recent research has demonstrated that routine antioxidant and alkaline therapy failed to show benefits in CI-AKI patients with high risk for renal complications. Mitophagy is a mechanism of selective autophagy, which controls mitochondrial quality and mitochondrial reactive oxygen species (ROS) through degradation of damaged mitochondria. The role of mitophagy and its regulation of apoptosis in CI-AKI are poorly understood. In this study, we demonstrated that mitophagy was induced in renal tubular epithelial cells (RTECs) during CI-AKI, both in vivo and in vitro. Meanwhile, contrast media-induced mitophagy was abolished when silencing PINK1 or PARK2 (Parkin), indicating a dominant role of the PINK1-Parkin pathway in mitophagy. Moreover, mitochondrial damage, mitochondrial ROS, RTEC apoptosis, and renal injury under contrast exposure were more severe in PINK1- or PARK2-deficient cells and mice than in wild-type groups. Functionally, PINK1-Parkin-mediated mitophagy prevented RTEC apoptosis and tissue damage in CI-AKI through reducing mitochondrial ROS and subsequent NLRP3 inflammasome activation. These results demonstrated that PINK1-Parkin-mediated mitophagy played a protective role in CI-AKI by reducing NLRP3 inflammasome activation.

Indexed as

Acute Kidney InjuryAnimalsApoptosisCell LineContrast MediaEpithelial CellsGene Expression RegulationHumansInflammasomesKidney Tubules, ProximalMiceMice, Inbred C57BLMice, KnockoutMitochondriaMitophagyNLR Family, Pyrin Domain-Containing 3 ProteinContrast MediaInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseparkin proteinProtein KinasesPTEN-Induced Putative KinaseReactive Oxygen SpeciesUbiquitin-Protein LigasesAcute kidney injuryApoptosisContrast mediaMitochondrial ROSMitophagyNLRP3 inflammasome

Identifiers

PMID31229841
PMCPMC6597739
OpenAlexW2951593518

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.