ArticleOsteoarthritis and cartilage2019
Rapid and durable photochemical bonding of cartilage using the porphyrin photosensitizer verteporfin.
Article in Osteoarthritis and cartilage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 2 citations in OpenAlex.
- Self-Organization Dynamics of Collagen-like Peptides Crosslinking Is Driven by Rose-Bengal-Mediated Electrostatic Bridges.Pharmaceutics · 2022Article
- Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo evaluate the effectiveness of verteporfin as a photosensitizer to photochemically bond articular cartilage tissues and determine bond durability in vitro.
designBond strength induced by verteporfin over a range of concentrations and light exposure conditions was investigated using a disk-annulus model and a pushout test. Exposure was parameterized by varying either irradiance or irradiation time. Bond robustness in a cell-mediated degeneration environment was examined by exposing newly bonded samples to interleukin-1 alpha for the first 4 days of a 7-day culture period, followed by mechanical testing and biochemical and cellular viability assays.
resultsPhotochemical bonding using verteporfin produced high bonding shear strengths at relatively low photosensitizer concentrations. Low exposures produced by either low irradiance or short irradiation time were sufficient to produce shear strengths comparable to those previously produced with phthalocyanine photosensitizers with substantially higher light exposure. Photochemically produced bonds were resistant to cell-mediated degeneration in vitro with no evident differences in cell viability among treatments.
conclusionsVerteporfin offers distinct advantages as a photosensitizer for photochemical bonding of articular cartilage due to the production of strong, durable bonds at relatively low light exposures. Further exploration may lead to clinically feasible strategies to augment cartilage repair techniques.
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Registered trials
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