Evidence map›Paper›PMID 31229667›Full record

ReviewMagnetic resonance imaging2019

Role of deep learning in infant brain MRI analysis.

Mahmoud Mostapha, Martin Styner

Abstract readReview
In one paragraph

Review in Magnetic resonance imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Article
  3. Deep learning in fetal, infant, and toddler neuroimaging research.Developmental cognitive neuroscience · 2026
    Review
  4. Article
  5. Article
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  7. Article
  8. Review
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  13. Review
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  16. Article
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  18. Article
  19. The Neurodevelopment of Autism from Infancy Through Toddlerhood.Neuroimaging clinics of North America · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mahmoud MostaphaDepartment of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States of America. Electronic address: mahmoudm@cs.unc.edu.
Martin StynerDepartment of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States of America; Neuro Image Research and Analysis Lab, Department of Psychiatry, University of North Carolina at Chapel Hill, NC 27599, United States of America. Electronic address: styner@unc.edu.

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Cellular and molecular mechanisms governing cortical surface area overgrowth in iPSC-derived neural cells from longitudinally characterized individuals with autismR01HD055741 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph Piven · 2007 to 2026
$52.6M
UNC BIRCWH CAREER DEVELOPMENT PROGRAMK12HD001441 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOGGESS, KIM A · 2000 to 2019
$9.3M
Preclinical CoreU54HD079124 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BELGER, AYSENIL · 2013 to 2019
$8.0M
Shape Analysis Toolbox: From medical images to quantitative insights of anatomyR01EB021391 · NIBIB · KITWARE, INC. · PI PANIAGUA, BEATRIZ · 2016 to 2024
$3.5M
NIA NIH HHS U01 AG024904NIBIB NIH HHS R01 EB021391NICHD NIH HHS K12 HD001441NICHD NIH HHS R01 HD055741NICHD NIH HHS U54 HD079124
6 · The paper itself

Abstract

Deep learning algorithms and in particular convolutional networks have shown tremendous success in medical image analysis applications, though relatively few methods have been applied to infant MRI data due numerous inherent challenges such as inhomogenous tissue appearance across the image, considerable image intensity variability across the first year of life, and a low signal to noise setting. This paper presents methods addressing these challenges in two selected applications, specifically infant brain tissue segmentation at the isointense stage and presymptomatic disease prediction in neurodevelopmental disorders. Corresponding methods are reviewed and compared, and open issues are identified, namely low data size restrictions, class imbalance problems, and lack of interpretation of the resulting deep learning solutions. We discuss how existing solutions can be adapted to approach these issues as well as how generative models seem to be a particularly strong contender to address them.

Indexed as

AlgorithmsBrainBrain DiseasesDeep LearningHumansImage Interpretation, Computer-AssistedInfantInfant, NewbornMagnetic Resonance ImagingNeural Networks, ComputerConvolutional neural networksDeep learningInfant MRIIsointense segmentationMachine learningMRIPrediction

Identifiers

PMID31229667
PMCPMC6874895

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.