Evidence map›Paper›PMID 31229508›Full record

ReviewSteroids2021

Membrane and nuclear initiated estrogenic regulation of homeostasis.

Todd L Stincic, Oline K Rønnekleiv, Martin J Kelly

Open access · greenAbstract readReview
In one paragraph

Review in Steroids, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Todd L StincicDepartment of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97239, United States.
Oline K RønnekleivDepartment of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97239, United States; Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, United States.
Martin J KellyDepartment of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97239, United States; Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, United States. Electronic address: kellym@ohsu.edu.
Oregon National Primate Research Center · USOregon Health & Science University · US

Funding

Sex Differences in the Control of FeedingR01DK068098 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI KELLY, MARTIN JEFFREY, RØNNEKLEIV, OLINE KARIN · 2005 to 2024
$7.1M
BETA ENDORPHIN NEURONS AND THE CONTROL OF HOMEOSTASISR01NS038809 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI KELLY, MARTIN JEFFREY · 1999 to 2018
$6.8M
Estrogen Modulation of Bursting Activity in GnRH NeuronsR01NS043330 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI RØNNEKLEIV, OLINE KARIN · 2004 to 2019
$5.5M
Beta Endorphin Neurons and the Control of HomeostasisR56NS038809 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI KELLY, MARTIN JEFFREY · 2009 to 2009
$481k
Crosstalk between Estrogen and Metabolic Hormone Signaling in Kisspeptin NeuronsR56DK068098 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI KELLY, MARTIN JEFFREY, RØNNEKLEIV, OLINE KARIN · 2020 to 2020
$262k
NIDDK NIH HHS R01 DK068098NIDDK NIH HHS R56 DK068098NINDS NIH HHS R01 NS038809NINDS NIH HHS R01 NS043330NINDS NIH HHS R56 NS038809
6 · The paper itself

Abstract

Reproduction and energy balance are inextricably linked in order to optimize the evolutionary fitness of an organism. With insufficient or excessive energy stores a female is liable to suffer complications during pregnancy and produce unhealthy or obesity-prone offspring. The quintessential function of the hypothalamus is to act as a bridge between the endocrine and nervous systems, coordinating fertility and autonomic functions. Across the female reproductive cycle various motivations wax and wane, following levels of ovarian hormones. Estrogens, more specifically 17β-estradiol (E2), coordinate a triumvirate of hypothalamic neurons within the arcuate nucleus (ARH) that govern the physiological underpinnings of these behavioral dynamics. Arising from a common progenitor pool of cells, this triumvirate is composed of the kisspeptin (Kiss1

Indexed as

EstrogensHomeostasisAnimalsCell MembraneCell NucleusFemaleHumansNeuronsEstrogensHypothalamusKisspeptin neuronsNeuropeptide Y/agouti-related peptide neuronsPeptidesProopiomelanocortin neuronsSynaptic transmission

Identifiers

PMID31229508
PMCPMC6923613
OpenAlexW2950582324

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.