ArticleAmerican journal of ophthalmology2019
Systemic Determinants of Peripapillary Vessel Density in Healthy African Americans: The African American Eye Disease Study.
Article in American journal of ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Prevalence and Risk Factors of Open-Angle Glaucoma in an Adult Chinese American Population: The Chinese American Eye Study.American journal of ophthalmology · 2025Article
- Ocular microvascular changes in COVID-19: role of hypoxia, D-dimer, IL-6 and systemic treatment.Pharmacological reports : PR · 2025Article
- Comparing structural and vascular parameters between advanced pseudoexfoliation glaucoma and primary open angle glaucoma using optical coherence tomography angiography.BMC ophthalmology · 2025Article
- Ocular and systemic determinants of perifoveal and macular vessel parameters in healthy African Americans.The British journal of ophthalmology · 2023Article
- Heterogeneity of Ocular Hemodynamic Biomarkers among Open Angle Glaucoma Patients of African and European Descent.Journal of clinical medicine · 2023Article
- Association of Neuroretinal Thinning and Microvascular Changes with Hypertension in an Older Population in Southern Italy.Journal of clinical medicine · 2022Article
- Combining Structural and Vascular Parameters to Discriminate Among Glaucoma Patients, Glaucoma Suspects, and Healthy Subjects.Translational vision science & technology · 2021Article
- Intrasession repeatability and intersession reproducibility of peripapillary OCTA vessel parameters in non-glaucomatous and glaucomatous eyes.The British journal of ophthalmology · 2021Observational
- Ocular blood flow as it relates to race and disease on glaucoma.Advances in ophthalmology and optometry · 2021Article
- Longer Axial Length Potentiates Relationship of Intraocular Pressure and Peripapillary Vessel Density in Glaucoma Patients.Investigative ophthalmology & visual science · 2021Article
- Quantitative assessment and determinants of the papillary microvasculature in healthy subjects.BMC ophthalmology · 2021Article
- Article
- Systemic Stressors and Retinal Microvascular Alterations in People Without Diabetes: The Kailuan Eye Study.Investigative ophthalmology & visual science · 2021Article
- Peripapillary Vessel Density in Eyes with Rhegmatogenous Retinal Detachment after Pars Plana Vitrectomy.Journal of ophthalmology · 2021Article
- Article
- Macular vessel density and foveal avascular zone parameters in patients after acute primary angle closure determined by OCT angiography.Scientific reports · 2020Article
- Effect of silicone oil on peripapillary capillary density in patients with rhegmatogenous retinal detachment.BMC ophthalmology · 2020Article
- Evaluation of the optic nerve head vessel density in the patients with asymmetric pseudoexfoliative glaucoma: an OCT angiography study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Article
- Eye Examination Recency among African American Older Adults with Chronic Medical Conditions.Healthcare (Basel, Switzerland) · 2020Article
- Optical Coherence Tomography Angiography in Glaucoma.Journal of glaucoma · 2020Review
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
purposeTo determine the relationship between systemic factors and radial peripapillary capillary (RPC) vessel density (VD) in healthy African American (AA) participants of the African American Eye Disease Study.
designA population-based, cross-sectional study.
methodsA total of 4135 eyes from 2127 AA participants aged 40 years and older in Inglewood, California, were imaged for 6×6-mm optic disc scans on a spectral-domain optical coherence tomography angiography (OCTA) device. Of these, 1029 eyes from 1029 participants who met the inclusion and exclusion criteria were analyzed, including only 1 eye per participant. Custom software was used to quantify RPC VD. Multivariate linear regression was used to identify systemic factors associated with RPC VD with a significance level set at 0.05. The contribution of each variable to the final model was estimated with the magnitude of standardized regression coefficients (SRCs). The fit of the final model was measured by R
resultsThe average RPC VD was 0.346±0.045. Controlling for signal strength, the systemic variables in the final multivariate model associated with reduced RPC VD were older age (β = -0.0123 per decade; SRC = -0.2733; P < .0001), male sex (β = -0.0067; SRC = -0.0716; P = .0060), and longer diabetes duration (β = -0.0022 per 5 years; SRC = -0.0527; P = .0427). The model R
conclusionsAge, sex, and systemic influences, such as diabetes duration, need to be considered when assessing changes in RPC VD in glaucoma and other ocular diseases. Longitudinal studies are needed to investigate whether reduced RPC VD and the factors that affect it are associated with an increased risk of developing glaucomatous nerve damage.
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