Evidence map›Paper›PMID 31229404›Full record

ArticleMolecular cell2019

An Oxygen-Dependent Interaction between FBXL5 and the CIA-Targeting Complex Regulates Iron Homeostasis.

Adarsh K Mayank, Vijaya Pandey, Ajay A Vashisht, William D Barshop, Shima Rayatpisheh, Tanu Sharma, Tisha Haque, David N Powers, James A Wohlschlegel

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Overlaps in mammalian iron and manganese homeostasis: recent advances.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Hypoxia-inducible factor-1 as targets for neuroprotection : from ferroptosis to Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
  12. Review
  13. Article
  14. Requirements for the biogenesis of [2Fe-2S] proteins in the human and yeast cytosol.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  15. Article
  16. Mechanisms controlling cellular and systemic iron homeostasis.Nature reviews. Molecular cell biology · 2024
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Adarsh K MayankDepartment of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Vijaya PandeyDepartment of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Ajay A VashishtDepartment of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
William D BarshopDepartment of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Shima RayatpishehDepartment of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Tanu SharmaDepartment of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Tisha HaqueDepartment of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
David N PowersDepartment of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
James A WohlschlegelDepartment of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. Electronic address: jwohl@ucla.edu.
University of California, Los Angeles · US

Funding

UCLA NIGMS T32 Program AssessmentT32GM007185 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TORRES, JORGE · 1985 to 2020
$21.7M
Proteolytic Control of Iron Metabolism by the Ubiquitin Ligase FBXL5R01GM089778 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WOHLSCHLEGEL, JAMES AKIRA · 2010 to 2023
$4.0M
Biogenesis of Extramitochondrial Iron-Sulfur Proteins in EukaryotesR01GM112763 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WOHLSCHLEGEL, JAMES AKIRA · 2015 to 2018
$982k
NIGMS NIH HHS R01 GM089778NIGMS NIH HHS R01 GM112763NIGMS NIH HHS T32 GM007185
6 · The paper itself

Abstract

The iron-sensing protein FBXL5 is the substrate adaptor for a SKP1-CUL1-RBX1 E3 ubiquitin ligase complex that regulates the degradation of iron regulatory proteins (IRPs). Here, we describe a mechanism of FBXL5 regulation involving its interaction with the cytosolic Fe-S cluster assembly (CIA) targeting complex composed of MMS19, FAM96B, and CIAO1. We demonstrate that the CIA-targeting complex promotes the ability of FBXL5 to degrade IRPs. In addition, the FBXL5-CIA-targeting complex interaction is regulated by oxygen (O

Indexed as

Cell Cycle ProteinsF-Box ProteinsHeLa CellsHomeostasisHumansIronIron-Regulatory ProteinsIron-Sulfur ProteinsMolecular ChaperonesMultiprotein ComplexesOxygenProteolysisTranscription FactorsUbiquitin-Protein Ligase ComplexesASF1A protein, humanCell Cycle ProteinsF-Box ProteinsFBXL5 protein, humanIronIron-Regulatory ProteinsIron-Sulfur ProteinsMolecular ChaperonesMultiprotein ComplexesOxygenTranscription FactorsUbiquitin-Protein Ligase ComplexesCIAO1CIA-targeting complexFAM96BFBXL5hypoxiairon homeostasisiron metabolismIRP1IRP2MMS19

Identifiers

PMID31229404
PMCPMC6660392
OpenAlexW2950143616

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.