Evidence map›Paper›PMID 31229392›Full record

ArticleAnnals of emergency medicine2019

Conversion to Persistent or High-Risk Opioid Use After a New Prescription From the Emergency Department: Evidence From Washington Medicaid Beneficiaries.

Zachary F Meisel, Nicoleta Lupulescu-Mann, Christina J Charlesworth, Hyunjee Kim, Benjamin C Sun

Registry-linked trialAbstract read
In one paragraph

Article in Annals of emergency medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04717518 (Anchoring Patients Pain Scores in the Emergency Department), which is not on this map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04717518 completednot on this mapstarted 2020, after this paper: background citation

Anchoring Patients Pain Scores in the Emergency Department

TypeobservationalSponsorCHRISTUS HealthRan2020 to 2021Enrolled108ConditionsAbdominal Pain, Chest Pain, Headache, Joint PainArmsMeasurement of Pain
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Article
  9. Effect of emergency department opioid prescribing on health outcomes.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025
    Article
  10. Article
  11. The burden of acute pain in the U.S. in the wake of the opioid crisis.Frontiers in pain research (Lausanne, Switzerland) · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Identifying Patient Characteristics Associated With Opioid Use to Inform Surgical Pain Management.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zachary F MeiselCenter for Emergency Care Policy Research, Department of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Leonard Davis Institute of Health Economics, and the Penn Injury Science Center, University of Pennsylvania, Philadelphia, PA; Center for Health Economics for Treatment Interventions of Substance Use Disorder, HIV, HCV. Electronic address: zfm@wharton.upenn.edu.
Nicoleta Lupulescu-MannCenter for Health Systems Effectiveness, Oregon Health & Science University, Portland, OR.
Christina J CharlesworthCenter for Health Systems Effectiveness, Oregon Health & Science University, Portland, OR.
Hyunjee KimCenter for Health Systems Effectiveness, Oregon Health & Science University, Portland, OR.
Benjamin C SunCenter for Emergency Care Policy Research, Department of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Leonard Davis Institute of Health Economics, and the Penn Injury Science Center, University of Pennsylvania, Philadelphia, PA; Center for Health Systems Effectiveness, Oregon Health & Science University, Portland, OR.

Funding

Utilization of health services after engagement with opioid use disorder (OUD) treatment provider by individuals with and without post-traumatic stress disorderP30DA040500 · NIDA · WEILL MEDICAL COLL OF CORNELL UNIV · PI Benjamin P. Linas · 2015 to 2026
$20.7M
EFFECTIVENESS OF PRESCRIPTION MONITORING PROGRAM USE IN EMERGENCY DEPARTMENTSR01DA036522 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI SUN, BENJAMIN C · 2014 to 2017
$1.5M
NIDA NIH HHS P30 DA040500NIDA NIH HHS R01 DA036522
6 · The paper itself

Abstract

STUDY

objectiveWe describe the overall risk and factors associated with transitioning to persistent opioid or high-risk use after an initial emergency department (ED) opioid prescription.

methodsA retrospective cohort study of Washington Medicaid beneficiaries was performed with linked Medicaid and prescription drug monitoring program files. We identified adults who had no record of opioid prescriptions in the previous 12 months, and who filled a new opioid prescription within 1 day of an ED discharge in 2014. We assessed the risk of persistent opioid use or high-risk prescription fills within 12 months after the index visit. Logistic regression was used to assess the association between pertinent variables and conversion to persistent or high-risk use.

resultsAmong 202,807 index ED visits, 23,381 resulted in a new opioid prescription. Of these, 13.7% led to persistent or high-risk opioid prescription fills within 12 months compared with 3.2% for patients who received no opioids at the index visit. Factors associated with increased likelihood of persistent opioid or high-risk prescription fills included a history of skeletal or connective-tissue disorder; neck, back, or dental pain; and a history of prescribed benzodiazepines. The highest conversion rates (37.3%) were observed among visits in which greater than or equal to 350 morphine milligram equivalents were prescribed. Conversion rates remained greater than 10% even among visits resulting in lower-dose opioid prescriptions.

conclusionMedicaid recipients are at moderate risk for conversion to persistent or high-risk opioid use after a new ED prescription. Longer or higher-dose prescriptions are associated with increased risk for conversion; however, even visits that lead to guideline-concordant prescriptions bear some risk for long-term or high-risk use.

Indexed as

Guideline AdherenceMedicaidPrescription Drug Monitoring ProgramsAdultAnalgesics, OpioidDrug PrescriptionsEmergency Service, HospitalFemaleGuidelines as TopicHumansMaleOpioid-Related DisordersPractice Patterns, Physicians'Prescription Drug MisusePrescription DrugsRetrospective StudiesAnalgesics, OpioidPrescription Drugs

Identifiers

PMID31229392
PMCPMC6864746

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.