ArticleEnvironment international2019
Perfluoroalkyl and polyfluoroalkyl substances and fetal thyroid hormone levels in umbilical cord blood among newborns by prelabor caesarean delivery.
Article in Environment international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Assessment of five typical environmental endocrine disruptors and thyroid cancer risk: a meta-analysis.Frontiers in endocrinology · 2023Pooled it
- Exposure to per- and Polyfluoroalkyl Substances and Markers of Liver Injury: A Systematic Review and Meta-Analysis.Environmental health perspectives · 2022Pooled it
- Per- and Polyfluoroalkyl Substances (PFAS) in Integrated Crop-Livestock Systems: Environmental Exposure and Human Health Risks.International journal of environmental research and public health · 2021Pooled it
- Prenatal PFAS Exposure in a Twin Pregnancy Cohort: Associations with Thyroid Disruption, Placental Malperfusion, and Fetal Growth Restriction.Environmental science & technology · 2026Article
- Thyroid disrupting effects of exposure to sunscreens: in vitro and in vivo evidence of the impact of organic UV-filters.Environmental health : a global access science source · 2025Review
- Review
- Association of per-and polyfluoroalkyl substances with thyroid hormones in the umbilical cord blood of neonates born by spontaneous delivery.Frontiers in public health · 2025Article
- Adverse outcome pathway for the neurotoxicity of Per- and polyfluoroalkyl substances: A systematic review.Eco-Environment & Health · 2024Review
- Associations between gestational exposure to perfluoroalkyl substances, fetal growth, and the mediation effect of thyroid hormones.Scientific reports · 2024Article
- Changing the structure of PFOA and PFOS: a chemical industry strategy or a solution to avoid thyroid-disrupting effects?Journal of endocrinological investigation · 2024Review
- Thyroid Hormone Biomonitoring: A Review on Their Metabolism and Machine-Learning Based Analysis on Effects of Endocrine Disrupting Chemicals.Environment & health (Washington, D.C.) · 2024Review
- Characterization of per- and polyfluoroalkyl substances (PFAS) concentrations in a community-based sample of infants from Samoa.Chemosphere · 2024Article
- Perfluorooctanesulfonic acid (PFOS) disrupts cadherin-16 in the developing rat thyroid gland.Current research in toxicology · 2024Article
- Review
- Emerging and Legacy Perfluoroalkyl Substances in Breastfed Chinese Infants: Renal Clearance, Body Burden, and Implications.Environmental health perspectives · 2023Article
- Developmental origins of metabolic diseases.Physiological reviews · 2021Review
- Exposure to perfluorobutane sulfonate and perfluorooctanesulfonic acid disrupts the production of angiogenesis factors and stress responses in human placental syncytiotrophoblast.Reproductive toxicology (Elmsford, N.Y.) · 2020Article
- Prenatal exposure to perfluoroalkyl substances and thyroid hormone concentrations in cord plasma in a Chinese birth cohort.Environmental health : a global access science source · 2020Article
- Exposure to Perflouroalkyl acids and foetal and maternal thyroid status: a review.Environmental health : a global access science source · 2020Review
- Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundPerfluoroalkyl and polyfluoroalkyl substances (PFAS) have been reported to disrupt the thyroid function. But epidemiological evidence on the association between PFAS and thyroid hormone (TH) levels in cord blood is scarce and controversial. We aimed to examine the association between cord blood PFAS concentrations and TH levels in prelabor caesarean deliveries.
methodsWe measured ten PFAS and three THs in cord blood in 568 prelabor caesarean deliveries. The associations between PFAS and TH levels were examined using multiple linear regression model and sparse partial least squares (SPLS) regression model.
resultsIn SPLS analyses, thyroid stimulating hormone (TSH) level decreased with increasing concentrations of perfluorooctane sulfonate (PFOS, β = -0.012, 95% confidence interval [CI]: -0.019, -0.005), perfluorononanoic acid (PFNA, β = -0.012, 95% CI: -0.019, -0.005), perfluorodecanoic acid (PFDA, β = -0.012, 95% CI: -0.02, -0.005), perfluoroundecanoic acid (PFUA, β = -0.013, 95% CI: -0.021, -0.006) and perfluorododecanoic acid (PFDoA, β = -0.013, 95% CI: -0.023, -0.006). Moreover, we found a positive association between PFDoA and free thyroxine (FT4) levels (β = 0.190, 95% CI: 0.063, 0.304) after adjusting for potential confounders. Free tri-iodothyronine (FT3) levels were positively associated with concentrations of PFOS (β = 0.059, 95% CI: 0.023, 0.100), but negatively associated with PFDoA (β = -0.153, 95% CI: -0.212, -0.106). We also observed gender disparity in the associations of PFAS exposure and FT3, FT4, TSH levels.
conclusionOur results suggest that prenatal exposure to certain PFAS may disrupt fetal thyroid function. The effect may be gender-specific.
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