Evidence map›Paper›PMID 31228634›Full record

ArticleHeart rhythm2019

Left atrial size and total atrial emptying fraction in atrial fibrillation progression.

Timm Seewöster, Ricardo A Spampinato, Philipp Sommer, Frank Lindemann, Cosima Jahnke, Ingo Paetsch, Gerhard Hindricks, Jelena Kornej

Abstract read
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In one paragraph

Article in Heart rhythm, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Impact of catheter ablation timing according to duration of atrial fibrillation history on arrhythmia recurrences and clinical outcomes: a meta-analysis.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Pooled it
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  7. Left atrial total emptying fraction measured by cardiovascular magnetic resonance imaging predicts low-voltage areas detected during electroanatomical mapping.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Timm SeewösterDepartment of Electrophysiology, Heart Center Leipzig, University of Leipzig, Leipzig, Germany. Electronic address: t.seewoester@yahoo.de.
Ricardo A SpampinatoDepartment of Cardiac Surgery, Herz- und Diabeteszentrum NRW, Bad Oeynhausen, Germany.
Philipp SommerDepartment of Electrophysiology, Herz- und Diabeteszentrum NRW, Bad Oeynhausen, Germany.
Frank LindemannDepartment of Electrophysiology, Heart Center Leipzig, University of Leipzig, Leipzig, Germany.
Cosima JahnkeDepartment of Electrophysiology, Heart Center Leipzig, University of Leipzig, Leipzig, Germany.
Ingo PaetschDepartment of Electrophysiology, Heart Center Leipzig, University of Leipzig, Leipzig, Germany.
Gerhard HindricksDepartment of Electrophysiology, Herz- und Diabeteszentrum NRW, Bad Oeynhausen, Germany; Department of Electrophysiology, Leipzig Heart Institute, Leipzig, Germany.
Jelena KornejDepartment of Electrophysiology, Heart Center Leipzig, University of Leipzig, Leipzig, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLeft atrial (LA) size and low-voltage areas (LVA) mirror atrial fibrillation (AF) progression. Whether these factors are important for the impairment of total atrial emptying fraction is understudied.

objectiveThe aim of the present analysis was to investigate the association between LA volume and total atrial emptying fraction with AF progression phenotypes: persistent AF and LVA.

methodsPatients undergoing first AF ablation were included in the analysis. LVA were determined using high-density maps and defined as <0.5 mV. All patients underwent cardiovascular magnetic resonance imaging before the intervention. Cardiovascular magnetic resonance data (LA volume, LA emptying fraction [LA-EF], and right atrial emptying fraction [RA-EF]) were measured in all patients.

resultsThe study population included 211 patients (65 ± 11 years; 124 (59%) men; 122 (58%) persistent AF; 54 (26%) LVA). There were 4 disease progression groups: paroxysmal AF without LVA, paroxysmal AF with LVA, persistent AF without LVA, and persistent AF with LVA. While LA volume increased according to the AF progression phenotype (98 ± 27, 145 ± 34, 134 ± 41, 141 ± 39 mL, respectively; P < .001), total LA-EF (51% ± 17%, 32% ± 17%, 33% ± 17%, 22% ± 11%; P < .001) and RA-EF (47% ± 13%, 36% ± 17%, 30% ± 16%, 23% ± 12%; P < .001) decreased. In multivariable analysis, age (odds ratio [OR] 1.084; 95% confidence interval [CI] 1.028-1.142; P = .003), persistent AF (OR 3.478; 95% CI 1.117-10.830; P = .031), and total LA-EF (OR 0.933; 95% CI 0.899-0.968; P < .001) showed a significant association for LVA. Using receiver operating characteristic curve analysis, LA-EF (area under the curve 0.778; 95% CI 0.711-0.846; P < .001) and RA-EF (area under the curve 0.726; 95% CI 0.650-0.802; P < .001) were significantly associated with the absence of LVA.

conclusionLVA and persistent AF are associated with worse total atrial emptying fraction.

Indexed as

AgedAtrial FibrillationCatheter AblationDisease ProgressionEpicardial MappingFemaleHeart AtriaHumansMagnetic Resonance ImagingMaleOrgan SizePhenotypeAtrial fibrillationCMRLA sizeLow-voltage areasTotal atrial emptying fraction

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.