ReviewSeminars in cell & developmental biology2020
Molecular mechanisms of epigenetic inheritance: Possible evolutionary implications.
Review in Seminars in cell & developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 104 citations in OpenAlex.
- Fetal programming in sheep: effects on pre- and postnatal development in lambs.Journal of animal science · 2020Pooled it
- Roles of Epigenetic Modifications in the Differentiation and Function of Pancreatic β-Cells.Frontiers in cell and developmental biology · 2020Pooled it
- Exploring the Role of DNA Methylation in the Epigenetic Landscape of Cancer.Biochemical genetics · 2026Review
- Epimutations: raw material for evolution?The EMBO journal · 2026Review
- Artificial Intelligence in Computer-Aided Drug Design (CADD) Tools for the Finding of Potent Biologically Active Small Molecules: Traditional to Modern Approach.Combinatorial chemistry & high throughput screening · 2026Review
- Review
- Transgenerational phenotypic plasticity of the two-spotted spider mite (Tetranychus urticae Koch) in response to abamectin.Experimental & applied acarology · 2025Article
- Epigenetics and individuality: from concepts to causality across timescales.Nature reviews. Genetics · 2025Review
- A Model of Epigenetic Inheritance Accounts for Unexpected Adaptation to Unforeseen Challenges.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Gene body methylation evolves during the sustained loss of parental care in the burying beetle.Nature communications · 2024Article
- Sex differences in fetal kidney reprogramming: the case in the renin-angiotensin system.Pediatric nephrology (Berlin, Germany) · 2024Review
- Heritable epigenetic variation facilitates long-term maintenance of epigenetic and genetic variation.G3 (Bethesda, Md.) · 2024Article
- Cisplatin exposure alters tRNA-derived small RNAs but does not affect epimutations in C. elegans.BMC biology · 2023Article
- Decoding the Influence of Obesity on Prostate Cancer and Its Transgenerational Impact.Nutrients · 2023Review
- Histone methylation regulates reproductive diapause in Drosophila melanogaster.PLoS genetics · 2023Article
- Pathological epigenetic events and reversibility review: the intersection between hallmarks of aging and developmental origin of health and disease.Epigenomics · 2023Review
- Stress Management in Plants: Examining Provisional and Unique Dose-Dependent Responses.International journal of molecular sciences · 2023Review
- Article
- BdLT-Seq as a barcode decay-based method to unravel lineage-linked transcriptome plasticity.Nature communications · 2023Article
- "Bet hedging" against climate change in developing and adult animals: roles for stochastic gene expression, phenotypic plasticity, epigenetic inheritance and adaptation.Frontiers in physiology · 2023Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Recently interest in multi-generational epigenetic phenomena have been fuelled by highly reproducible intergenerational and transgenerational inheritance paradigms in several model organisms. Such paradigms are essential in order to begin to use genetics to unpick the mechanistic bases of how epigenetic information may be transmitted between generations; indeed great strides have been made towards understanding these mechanisms. Far less well understood is the relationship between epigenetic inheritance, ecology and evolution. In this review I focus on potential connections between laboratory studies of transgenerational epigenetic inheritance phenomena and evolutionary processes that occur in natural populations. In the first section, I consider whether transgenerational epigenetic inheritance might provide an advantage to organisms over the short term in adapting to their environment. Second, I consider whether epigenetic changes can contribute to the evolution of species by contributing to stable phenotypic variation within a population. Finally I discuss whether epigenetic changes could influence evolution by either directly or indirectly promoting DNA sequence changes that could impact phenotypic divergence. Additionally, I will discuss how epigenetic changes could influence the evolution of human cancer and thus be directly relevant for the development of this disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.