ArticlePhysiology & behavior2019
Capsaicin-induced visceral deafferentation does not attenuate flavor conditioning by intragastric fat infusions in mice.
Article in Physiology & behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Separate gut-brain circuits for fat and sugar reinforcement combine to promote overeating.Cell metabolism · 2024Article
- AgRP neuron activity promotes associations between sensory and nutritive signals to guide flavor preference.Molecular metabolism · 2023Article
- AgRP neuron activity promotes associations between sensory and nutritive signals to guide flavor preference.bioRxiv : the preprint server for biology · 2023Article
- Learning of food preferences: mechanisms and implications for obesity & metabolic diseases.International journal of obesity (2005) · 2021Review
- Gut-brain communication and obesity: understanding functions of the vagus nerve.The Journal of clinical investigation · 2021Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The postoral actions of sugar and fat can rapidly stimulate the intake of and preference for flavors associated with these nutrients via a process known as appetition. Prior findings revealed that postoral glucose appetition is not attenuated following capsaicin-induced visceral deafferentation. The present experiment determined if capsaicin treatment altered fat appetition in C57BL/6 mice. Following capsaicin (Cap) or control (Con) treatment, mice were fitted with chronic intragastric (IG) catheters. They were then given 1-h sessions with a flavored saccharin solution (CS-) paired with IG water infusion or a different flavor (CS+) paired with IG 6.4% fat infusion. IG fat stimulated CS+ intakes in both Cap and Con mice, and the groups displayed similar preferences for CS+ over CS- in two-choice tests. These results confirm prior reports of normal fat conditioning in rats exposed to capsaicin or vagal deafferentation surgery. In contrast, other recent findings indicate that total or selective vagotomy alters the preference of mice for dilute vs. concentrated fat sources.
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Registered trials
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