SynthesisThe Annals of thoracic surgery2019
Computed Tomography-Assessed Skeletal Muscle Mass as a Predictor of Outcomes in Lung Cancer Surgery.
Synthesis in The Annals of thoracic surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 5 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Guideline for the Comprehensive Perioperative Management of Older Patients With Lung Cancer (2025).Journal of evidence-based medicine · 2026Guideline
- Highlighting sarcopenia management in cancer treatments: evidence from umbrella meta-analysis.Frontiers in nutrition · 2026Pooled it
- Weight loss as a predictor of reduced survival in patients with lung cancer: a systematic review with meta-analysis.International journal of obesity (2005) · 2025Pooled it
- Sarcopenia predicts postoperative complications in head and neck cancer: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Pooled it
- Prognostic value of sarcopenia in survivors of hematological malignances undergoing a hematopoietic stem cell transplantation: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Pooled it
- Prophylactic high-flow nasal oxygen vs. conventional oxygen for prevention of postoperative respiratory complications: a randomized trial.Critical care (London, England) · 2026Trial
- Prognostic significance of predicted skeletal muscle index after curative-intent resection for non-small cell lung cancer.International journal of clinical oncology · 2026Article
- Pragmatic Screening for Sarcopenia in Non-Small Cell Lung Cancer: Development and Internal Validation of a Prospective Risk Model Integrating T12 CT Indices and Routine Clinical Variables.Cancer medicine · 2026Article
- CT-derived thoracic muscle thickness is associated with prolonged hospitalization after video-assisted thoracoscopic surgery.Journal of thoracic disease · 2026Article
- The Interplay of Preoperative Sarcopenia, Systemic Inflammation, and Neoadjuvant Therapy in Resectable NSCLC-Identifying the Gap: A Narrative Review of Surgical and Oncological Outcomes.Medicina (Kaunas, Lithuania) · 2026Review
- Skeletal Muscle Gauge as a Prognosticator of Survival in Resected Early-Stage Non-small Cell Lung Cancer.Annals of surgical oncology · 2026Article
- Skeletal Muscle Gauge as a Prognosticator of Survival in Resected Early-Stage Non-small Cell Lung Cancer.Annals of surgical oncology · 2026Article
- CT-Assessed Body Composition as Predictor of Post-Operative Complications in Lung Cancer Patients.Cancers · 2026Review
- Tibialis anterior pennation angle at ICU admission and 60-day mortality in critically ill patients: a prospective observational study.Frontiers in medicine · 2026Article
- Sarcopenia is a bad harbinger of cancer-related survival in rectal cancer.Annals of medicine · 2025Article
- Impact of sarcopenia on early surgical outcomes in elderly patients following lung cancer surgery: a prospective cohort study.Journal of thoracic disease · 2025Article
- Imaging Cancer-associated Cachexia: Utilizing Clinical Imaging Modalities for Early Diagnosis.Radiology. Imaging cancer · 2025Review
- HISLIS: Histology, Sarcopenia, and Lung Inflammation Score-A New Perspective for Lung Cancer Patients?Life (Basel, Switzerland) · 2025Article
- Novel multimodal intervention for surgical prehabilitation on functional recovery and muscle characteristics in patients with non-small cell lung cancer: study protocol for a randomised controlled trial (MMP-LUNG).BMJ open respiratory research · 2025Article
- Evaluation of nutritional parameters that may be associated with survival in patients with locally advanced non-small cell lung carcinoma receiving definitive concurrent chemoradiotherapy: retrospective study conducted in a tertiary pulmonary hospital.Japanese journal of radiology · 2025Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSarcopenia is characterized by loss of skeletal muscle and strength, associated with aging, poor nutrition, sedentary lifestyle, and long-term illness. We sought to evaluate the current evidence on the prevalence of sarcopenia assessed by computed tomography (CT) imaging in patients undergoing lung cancer resection and its predictive value for perioperative and long-term outcomes.
methodsWe performed a systematic literature search of the PubMed/MEDLINE database to identify studies that examined CT-assessed muscle mass and outcomes of patients undergoing lung resection. Pooled odds ratio for complications and hazard ratio for survival with 95% confidence intervals (CI) were generated using the Mantel-Haenszel or inverse variance methods with random effects models.
resultsNine observational studies met the inclusion criteria. Four studies measured skeletal muscle at the thoracic level (T5, T12, T8) and 5 studies at the lumbar level (L3). The prevalence of sarcopenia by CT skeletal muscle measurements ranged from 22.4% to 55.8%, with an average of 42.8% in 1010 patients. Four of 6 studies that reported perioperative outcomes were included in the meta-analysis, which showed higher risk of perioperative complications for patients with sarcopenia (odds ratio 2.51, 95% CI: 1.55-4.08, P < .001). Sarcopenia was associated with worse survival in 6 of 7 studies that evaluated long-term outcomes after lung cancer resection (hazard ratio 2.31, 95% CI: 1.26-4.24, P = .007).
conclusionsSarcopenia can be frequently detected in patients undergoing lung cancer resection with the use of CT-based muscle measurements. Sarcopenia was associated with greater risk of perioperative complications and worse long-term prognosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.