Evidence map›Paper›PMID 31228354›Full record

ArticleThoracic cancer2019

Radiation-induced tumor immunity in patients with non-small cell lung cancer.

Natalie A Lockney, Mei Zhang, Christopher G Morris, Romaine Charles Nichols, Paul Okunieff, Steven Swarts, Zhenhuan Zhang, Bingrong Zhang, Amy Zhang, Bradford S Hoppe

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Thoracic cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

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  10. Abscopal effect of local irradiation treatment for thymoma: a case report.American journal of translational research · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Natalie A LockneyDepartment of Radiation Oncology, University of Florida, Gainesville, USA.
Mei ZhangDepartment of Radiation Oncology, University of Florida, Gainesville, USA.
Christopher G MorrisDepartment of Radiation Oncology, University of Florida, Gainesville, USA.
Romaine Charles NicholsDepartment of Radiation Oncology, University of Florida, Gainesville, USA.
Paul OkunieffDepartment of Radiation Oncology, University of Florida, Gainesville, USA.
Steven SwartsDepartment of Radiation Oncology, University of Florida, Gainesville, USA.
Zhenhuan ZhangDepartment of Radiation Oncology, University of Florida, Gainesville, USA.
Bingrong ZhangDepartment of Radiation Oncology, University of Florida, Gainesville, USA.
Amy ZhangDepartment of Radiation Oncology, University of Florida, Gainesville, USA.
Bradford S HoppeDepartment of Radiation Oncology, University of Florida, Gainesville, USA.ORCID 0000-0002-2312-5418
University of Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRadiation-induced tumor immunity (RITI) influences primary tumor growth and development of metastases in preclinical cancer models with conventional radiotherapy. Antigen-specific immune responses have also been shown for prostate cancer treated with radiotherapy. We examined whether RITI can be induced in patients with non-small cell lung cancer (NSCLC) following proton radiotherapy.

methodsPre- and post-radiotherapy plasma samples from 26 patients with nonmetastatic NSCLC who received radiotherapy between 2010 and 2012 were evaluated by western blotting for IgG and IgM bands to assess RITI response to tumor antigens from lung cancer cell lines. Statistical analysis was used to evaluate any correlation among IgG or IgM and clinical outcomes.

resultsTwenty-one patients received proton therapy at 2 GyRBE/fraction (n = 17) or 6-12 Gy/fraction (n = 4); five received photon therapy at 2-2.5 GyRBE/fraction. Compared with the pretreatment baseline, new IgG or IgM binding was detected in 27% and 50% of patients, respectively. New IgG bands were detected in the 25-37 kD, 50-75 kD, and 75-100 kD ranges. New IgM bands were detected in the 20-25 kD, 25-37 kD, 37-50 kD, 50-75 kD, and 75-100 kD ranges. There was no difference in IgG and/or IgM RITI response in patients treated with photons versus protons, or in patients who received SBRT compared to standard fractionation (P > 0.05). There was no difference in overall survival, metastasis-free survival, or local control based on IgG and/or IgM RITI response (P > 0.05).

conclusionRITI can be induced in patients with NSCLC through upregulated IgG and/or IgM. RITI response was not associated with proton versus photon therapy or with clinical outcomes in this small cohort and should be examined in a larger cohort in future studies.

Indexed as

A549 CellsAgedAged, 80 and overAntibodies, NeoplasmCarcinoma, Non-Small-Cell LungCell Line, TumorDose Fractionation, RadiationFemaleHumansImmunoglobulin GImmunoglobulin MLung NeoplasmsMaleMiddle AgedProspective StudiesProton TherapyAntibodies, NeoplasmImmunoglobulin GImmunoglobulin MAbscopal effectlung cancerradiation therapytumor immunity

Identifiers

PMID31228354
PMCPMC6610279
OpenAlexW2951434175

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.