ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2019
Thyroid hormone coordinates developmental trajectories but does not underlie developmental truncation in danionins.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Zebrafish relatives as models for functional comparative genetics and genomics.Nature reviews. Genetics · 2026Review
- Whole-body single-cell atlas of an adult vertebrate in homeostasis and regeneration.bioRxiv : the preprint server for biology · 2026Article
- Zebrafish neuromast development: a target for endocrine disrupting chemicals?Frontiers in toxicology · 2026Article
- Article
- Experimentally Manipulating the Thyroid Hormone Axis in Zebrafish.Methods in molecular biology (Clifton, N.J.) · 2025Review
- The Impact of Polychlorinated Biphenyls on the Development of Zebrafish (Biomedicines · 2024Article
- Cross-species applicability of an adverse outcome pathway network for thyroid hormone system disruption.Toxicological sciences : an official journal of the Society of Toxicology · 2023Review
- Thyroid hormone regulates proximodistal patterning in fin rays.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Thyroid hormone as a temporal switch in mouse development.European thyroid journal · 2023Review
- Thyroid hormone shapes craniofacial bones during postembryonic zebrafish development.Evolution & development · 2022Article
- The Evolution of Feeding Mechanics in the Danioninae, or Why Giant Danios Don't Suck Like Zebrafish.Integrative organismal biology (Oxford, England) · 2022Article
- Thyroid hormone regulates abrupt skin morphogenesis during zebrafish postembryonic development.Developmental biology · 2021Article
- Anthropogenic stressors impact fish sensory development and survival via thyroid disruption.Nature communications · 2020Article
- Thyroid hormone modulation during zebrafish development recapitulates evolved diversity in danionin jaw protrusion mechanics.Evolution & development · 2019Article
- Staging and normal table of postembryonic development of the clownfish (Amphiprion ocellaris).Developmental dynamics : an official publication of the American Association of Anatomists · 2019Article
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
backgroundDifferences in postembryonic developmental trajectories can profoundly alter adult phenotypes and life histories. Thyroid hormone (TH) regulates metamorphosis in many vertebrate taxa with multiphasic ecologies, and alterations to TH metabolism underlie notable cases of paedomorphosis in amphibians. We tested the requirement for TH in multiple postembryonic developmental processes in zebrafish, which has a monophasic ecology, and asked if TH production was compromised in paedomorphic Danionella.
resultsWe showed that TH regulates allometric growth in juvenile zebrafish, and inhibits relative head growth. The lateral line system showed differential requirements for TH: the hormone promotes canal neuromast formation and inhibits neuromast proliferation in the head, but causes expansion of the neuromast population in the trunk. While Danionella morphology resembled that of larval zebrafish, the two Danionella species analyzed were not similar to hypothyroid zebrafish in their shape or neuromast distribution, and both possessed functional thyroid follicles.
conclusionsAlthough zebrafish do not undergo a discrete ecological transformation, we found that multiple tissues undergo transitions in developmental trajectories that are dependent on TH, suggesting the TH axis and its downstream pathways as likely targets for adaptation. Nonetheless, we found no evidence that evolutionary paedomorphosis in Danionella is the result of compromised TH production.
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