ArticleEuropean heart journal2020
Myocardial blood flow reserve assessed by positron emission tomography myocardial perfusion imaging identifies patients with a survival benefit from early revascularization.
Article in European heart journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 2 of them syntheses that pooled it.
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Who cites it
77 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Role of Artificial Intelligence in Predicting Outcomes by Cardiovascular Magnetic Resonance: A Comprehensive Systematic Review.Medicina (Kaunas, Lithuania) · 2022Pooled it
- Coronary flow reserve and cardiovascular outcomes: a systematic review and meta-analysis.European heart journal · 2022Pooled it
- Optimal medical care and coronary flow capacity-guided myocardial revascularization vs usual care for chronic coronary artery disease: the CENTURY trial.European heart journal · 2025Trial
- Variation in Health Status With Invasive vs Conservative Management of Chronic Coronary Disease.Journal of the American College of Cardiology · 2024Trial
- The Prognostic Significance of Quantitative Myocardial Perfusion: An Artificial Intelligence-Based Approach Using Perfusion Mapping.Circulation · 2020Trial
- Reduced ¹³N-Ammonia PET Myocardial Flow Reserve and Heart-Failure-Related Risk Independent of Relative Ischemia in Chronic Coronary Syndrome.European journal of nuclear medicine and molecular imaging · 2026Article
- The Effect of Motion Correction on Quantitative Perfusion Indices and Threshold-Based Interpretation inDiagnostics (Basel, Switzerland) · 2026Article
- Establishing normal myocardial blood flow and myocardial flow reserve values: a rubidium-82 positron emission tomography study.European journal of nuclear medicine and molecular imaging · 2026Article
- Inter-Observer Reliability in Myocardial Blood Flow Measurement Using Rb-82-PET/CT.Tomography (Ann Arbor, Mich.) · 2026Article
- Cardiac Positron Emission Tomography Myocardial Perfusion Imaging: Seeing Beyond Perfusion.World journal of nuclear medicine · 2026Review
- Real-world application of deep learning for ECG-based prediction of coronary artery disease and revascularization needs.European heart journal. Digital health · 2025Article
- The REgistry of Flow and Perfusion Imaging for Artificial Intelligence with positron emission tomography (REFINE PET):Rationale and design.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2025Article
- Myocardial perfusion and oxidative metabolism in healthy subjects: sex-specific insights from vasodilatory stressEJNMMI research · 2025Article
- Left ventricular ejection fraction reserve and its association with myocardial perfusion, coronary calcification, and strain in type 2 diabetes without overt cardiovascular disease.Cardiovascular diabetology · 2025Article
- What role for cardiac imaging in chronic coronary syndromes: review of the literature in light of the latest recommendations.European heart journal. Imaging methods and practice · 2025Review
- Deep learning-quantified body composition from positron emission tomography/computed tomography and cardiovascular outcomes: a multicentre study.European heart journal · 2025Article
- Independent prognostic significance of myocardial flow reserve over coronary artery calcium, myocardial perfusion, and clinical variables in patients without known coronary artery disease, according to diabetes status.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2025Article
- Emerging Applications of Positron Emission Tomography in Coronary Artery Disease.Journal of personalized medicine · 2025Review
- Effect of exercise training on cardiac function and glucose metabolism in the ischemic border zone: insights from multi-modal imaging techniques.Frontiers in cardiovascular medicine · 2025Article
- Visually assessed ischemia on cardiac magnetic resonance, but not quantitative perfusion metrics, predicts symptomatic improvement in coronary artery bypass.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025Article
17 more citing papers are in PubMed but not listed here.
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10 authors.
Funding
Abstract
aimsPositron emission tomography (PET) myocardial perfusion imaging (MPI) can non-invasively measure myocardial blood flow reserve (MBFR). We aimed to examine whether MBFR identifies patients with a survival benefit after revascularization, helping to guide post-test management. METHODS AND
resultsWe examined all-cause mortality in 12 594 consecutive patients undergoing Rb82 rest/stress PET MPI from January 2010 to December 2016, after excluding those with cardiomyopathy, prior coronary artery bypass surgery (CABG), and missing MBFR. Myocardial blood flow reserve was calculated as the ratio of stress to rest absolute myocardial blood flow. A Cox model adjusted for patient and test characteristics, early revascularization (percutaneous coronary intervention or CABG ≤90 days of MPI), and the interaction between MBFR and early revascularization was developed to identify predictors of all-cause mortality. After a median follow-up of 3.2 years, 897 patients (7.1%) underwent early revascularization and 1699 patients (13.5%) died. Ischaemia was present in 4051 (32.3%) patients, with 1413 (11.2%) having ≥10% ischaemia. Mean MBFR was 2.0 ± 1.3, with MBFR <1.8 in 4836 (38.5%). After multivariable adjustment, every 0.1 unit decrease in MBFR was associated with 9% greater hazard of all-cause death (hazard ratio 1.09, 95% confidence interval 1.08-1.10; P < 0.001). There was a significant interaction between MBFR and early revascularization (P < 0.001); such that patients with MBFR ≤1.8 had a survival benefit with early revascularization, regardless of type of revascularization or level of ischaemia.
conclusionMyocardial blood flow reserve on PET MPI is associated with all-cause mortality and can identify patients who receive a survival benefit with early revascularization compared to medical therapy. This may be used to guide revascularization, and prospective validation is needed.
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