Evidence map›Paper›PMID 31227953›Full record

ArticleThe international journal of cardiovascular imaging2019

Usefulness of layer-specific strain in diagnosis of coronary artery disease in patients with stable angina pectoris.

Christoffer A Hagemann, Søren Hoffmann, Rikke A Hagemann, Thomas Fritz-Hansen, Flemming J Olsen, Peter G Jørgensen, Tor Biering-Sørensen

Abstract read
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In one paragraph

Article in The international journal of cardiovascular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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  14. Two-Dimensional Speckle Tracking Echocardiography Identifies Coronary Artery Disease in 690 Patients: A Retrospective Study from a Single Center.Medical science monitor : international medical journal of experimental and clinical research · 2021
    Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Christoffer A HagemannDepartment of Cardiology, Herlev & Gentofte Hospital, Faculty of Health Sciences, University of Copenhagen, Kildegårdsvej 28, 2900, Hellerup, Denmark. christofferhag@hotmail.com.ORCID http://orcid.org/0000-0001-6917-3223
Søren HoffmannDepartment of Anaesthesiology and Intensive Care Medicine, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400, Copenhagen, Denmark.
Rikke A HagemannDepartment of Cardiology, Herlev & Gentofte Hospital, Faculty of Health Sciences, University of Copenhagen, Kildegårdsvej 28, 2900, Hellerup, Denmark.
Thomas Fritz-HansenDepartment of Cardiology, Herlev & Gentofte Hospital, Faculty of Health Sciences, University of Copenhagen, Kildegårdsvej 28, 2900, Hellerup, Denmark.
Flemming J OlsenDepartment of Cardiology, Herlev & Gentofte Hospital, Faculty of Health Sciences, University of Copenhagen, Kildegårdsvej 28, 2900, Hellerup, Denmark.
Peter G JørgensenDepartment of Cardiology, Herlev & Gentofte Hospital, Faculty of Health Sciences, University of Copenhagen, Kildegårdsvej 28, 2900, Hellerup, Denmark.
Tor Biering-SørensenDepartment of Cardiology, Herlev & Gentofte Hospital, Faculty of Health Sciences, University of Copenhagen, Kildegårdsvej 28, 2900, Hellerup, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Novel software allows for layer-specific evaluation of myocardial strain by speckle tracking echocardiography (2DSTE). However, the potential of layer-specific strain at rest for diagnosing coronary artery disease (CAD) in patients with suspected stable angina pectoris (SAP) remains unknown. Our objective was to evaluate the usefulness of layer-specific 2DSTE at rest for diagnosis of CAD in patients with SAP. In total, 285 patients referred with clinically suspected SAP, normal ejection fraction, and no previous cardiac history were prospectively enrolled. All patients were examined by echocardiography, including 2DSTE, exercise ECG, and coronary angiography (CAG). Layer-specific 2DSTE was performed in three apical views to provide longitudinal peak systolic strains. Stenosis ≥ 70% in ≥ 1 major coronary artery on CAG was considered as significant CAD. Of 285 patients included, 104 had significant CAD (36%). Endocardial, epicardial, and mid-myocardial GLS were all significantly impaired in CAD patients (P < 0.001). Multivariable analysis including baseline clinical parameters, conventional echocardiographic measurements, Duke score, and layer-specific strain measurements revealed epicardial [odds ratio 1.19 (P = 0.048)] and mid-myocardial [odds ratio 1.16 (P = 0.047)] global longitudinal strain (GLS) as the only independent predictors of CAD. In direct comparison, epicardial and mid-myocardial GLS had a significantly higher diagnostic performance compared to endocardial GLS (P = 0.038 and P = 0.031, respectively). In conclusion, layer-specific GLS from 2DSTE at rest was significantly impaired in patients with significant CAD. In addition, epicardial and mid-myocardial GLS were independent predictors of CAD.

Indexed as

EchocardiographyMyocardial ContractionVentricular Function, LeftAngina, StableCoronary Artery DiseaseHumansPredictive Value of TestsPrognosisProspective StudiesReproducibility of ResultsSeverity of Illness IndexAnginaCoronary artery diseaseEchocardiographySpeckle tracking

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.