Evidence map›Paper›PMID 31227880›Full record

ArticleEuropean radiology2019

Impact of sublingual nitroglycerin dosage on FFR

Kenneth R Holmes, Tim A Fonte, Jonathan Weir-McCall, Malcolm Anastasius, Philipp Blanke, Geoffrey W Payne, Jen Ellis, Darra T Murphy, Charles Taylor, Jonathon A Leipsic and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Kenneth R HolmesDepartment of Radiology, St Paul's Hospital and University of British Columbia, 1081 Burrard St., Vancouver, British Columbia, V6Z 1Y6, Canada.
Tim A FonteHeartFlow Inc., Redwood City, CA, USA.
Jonathan Weir-McCallDepartment of Radiology, St Paul's Hospital and University of British Columbia, 1081 Burrard St., Vancouver, British Columbia, V6Z 1Y6, Canada.
Malcolm AnastasiusDepartment of Radiology, St Paul's Hospital and University of British Columbia, 1081 Burrard St., Vancouver, British Columbia, V6Z 1Y6, Canada.
Philipp BlankeDepartment of Radiology, St Paul's Hospital and University of British Columbia, 1081 Burrard St., Vancouver, British Columbia, V6Z 1Y6, Canada.
Geoffrey W PayneUniversity of Northern British Columbia, Prince George, Canada.
Jen EllisDepartment of Radiology, St Paul's Hospital and University of British Columbia, 1081 Burrard St., Vancouver, British Columbia, V6Z 1Y6, Canada.
Darra T MurphyDepartment of Radiology, St Paul's Hospital and University of British Columbia, 1081 Burrard St., Vancouver, British Columbia, V6Z 1Y6, Canada.
Charles TaylorHeartFlow Inc., Redwood City, CA, USA.
Jonathon A LeipsicDepartment of Radiology, St Paul's Hospital and University of British Columbia, 1081 Burrard St., Vancouver, British Columbia, V6Z 1Y6, Canada.
Stephanie L SellersDepartment of Radiology, St Paul's Hospital and University of British Columbia, 1081 Burrard St., Vancouver, British Columbia, V6Z 1Y6, Canada. stephanie.sellers@hli.ubc.ca.ORCID http://orcid.org/0000-0002-3539-5730
University of British Columbia · CAHeartFlow (United States) · USUniversity of Northern British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesFractional flow reserve computed tomography (FFR

methodsEighty patients with repeat coronary CT angiograms (CCTAs) with different sublingual spray NTG doses (0.4 mg and 0.8 mg) were retrospectively analyzed with 45 patients excluded. Patient and scan demographics, post-stenosis and nadir FFR

resultsThirty-five patients were included (time between CCTAs, 3.9 ± 1.6 years). Segment involvement score was 2.4 ± 3.3 and 2.8 ± 3.4 at initial and repeat CCTA (0.4 and 0.8 mg NTG), respectively (p = 0.004). There was similar image quality (4.1 ± 0.7 vs 4.1 ± 0.8; p = 0.51). Nadir FFR

conclusionsUse of 0.8 mg versus 0.4 mg of NTG in routine clinical CCTAs significantly increased coronary volume determined from FFR KEY POINTS: • Fractional flow reserve from computed tomography (FFR

Indexed as

Administration, SublingualComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseFemaleFractional Flow Reserve, MyocardialHumansMaleMiddle AgedMyocardiumNitroglycerinOrgan SizePredictive Value of TestsRetrospective StudiesVasodilator AgentsNitroglycerinVasodilator AgentsComputed tomography angiographyCoronary artery diseaseNitroglycerinVasodilation

Identifiers

PMID31227880
OpenAlexW2949819707

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.