Evidence map›Paper›PMID 31227879›Full record

ArticleEuropean radiology2019

Direct attenuation correction of brain PET images using only emission data via a deep convolutional encoder-decoder (Deep-DAC).

Isaac Shiri, Pardis Ghafarian, Parham Geramifar, Kevin Ho-Yin Leung, Mostafa Ghelichoghli, Mehrdad Oveisi, Arman Rahmim, Mohammad Reza Ay

Abstract read
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In one paragraph

Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 102 citations in OpenAlex.

  1. Beyond CT: Attenuation correction for stand-alone brain PET.Zeitschrift fur medizinische Physik · 2026
    Review
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  5. Clinical evaluation of deep learning-based CT-free PET reconstruction image: a dual-center study.European journal of nuclear medicine and molecular imaging · 2026
    Article
  6. On Hallucinations in Artificial Intelligence-Generated Content for Nuclear Medicine Imaging (the DREAM Report).Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Review
  7. Article
  8. Review
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  10. Article
  11. Review
  12. Article
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  14. Article
  15. Deep-learning-based Attenuation Correction forMolecular imaging and radionuclide therapy · 2024
    Article
  16. Article
  17. Review
  18. Article
  19. Context-Aware Transformer GAN for Direct Generation of Attenuation and Scatter Corrected PET Data.IEEE transactions on radiation and plasma medical sciences · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 3 countries.

Isaac ShiriResearch Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran.
Pardis GhafarianChronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. pardis.ghafarian@sbmu.ac.ir.
Parham GeramifarResearch Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Kevin Ho-Yin LeungDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Mostafa GhelichoghliDepartment of Biomedical and Health Informatics, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Science, Tehran, Iran.
Mehrdad OveisiDepartment of Biomedical and Health Informatics, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Science, Tehran, Iran.
Arman RahmimDepartment of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA.
Mohammad Reza AyResearch Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran. mohammadreza_ay@sina.tums.ac.ir.ORCID http://orcid.org/0000-0002-5383-4418
University of British Columbia · CAJohns Hopkins University · USMasih Daneshvari Hospital · IRShaheed Rajaei Cardiovascular Medical and Research Center · IRShariati Hospital · IRSina Hospital · IRTehran University of Medical Sciences · IR

Funding

Tehran University of Medical Sciences and Health Services 97-01-30-38001
6 · The paper itself

Abstract

objectiveTo obtain attenuation-corrected PET images directly from non-attenuation-corrected images using a convolutional encoder-decoder network.

methodsBrain PET images from 129 patients were evaluated. The network was designed to map non-attenuation-corrected (NAC) images to pixel-wise continuously valued measured attenuation-corrected (MAC) PET images via an encoder-decoder architecture. Image quality was evaluated using various evaluation metrics. Image quantification was assessed for 19 radiomic features in 83 brain regions as delineated using the Hammersmith atlas (n30r83). Reliability of measurements was determined using pixel-wise relative errors (RE; %) for radiomic feature values in reference MAC PET images.

resultsPeak signal-to-noise ratio (PSNR) and structural similarity index metric (SSIM) values were 39.2 ± 3.65 and 0.989 ± 0.006 for the external validation set, respectively. RE (%) of SUV

conclusionsDirect AC of PET images using deep convolutional encoder-decoder networks is a promising technique for brain PET images. The proposed deep learning method shows significant potential for emission-based AC in PET images with applications in PET/MRI and dedicated brain PET scanners. KEY POINTS: • We demonstrate direct emission-based attenuation correction of PET images without using anatomical information. • We performed radiomics analysis of 83 brain regions to show robustness of direct attenuation correction of PET images. • Deep learning methods have significant promise for emission-based attenuation correction in PET images with potential applications in PET/MRI and dedicated brain PET scanners.

Indexed as

AdolescentAdultAgedBrainBrain DiseasesChildFemaleHumansImage Interpretation, Computer-AssistedMaleMiddle AgedNeuroimagingPositron-Emission TomographyReproducibility of ResultsYoung AdultArtificial intelligenceBrain imagingDeep learningPositron emission tomographyRadiomics

Identifiers

PMID31227879
OpenAlexW2949076424

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.