Evidence map›Paper›PMID 31227785›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2019

Medication use in infants with severe bronchopulmonary dysplasia admitted to United States children's hospitals.

Nicolas A Bamat, Haresh Kirpalani, Chris Feudtner, Erik A Jensen, Matthew M Laughon, Huayan Zhang, Heather M Monk, Molly Passarella, Scott A Lorch

Abstract read
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
  2. Association between route of furosemide administration and diuretic response in very preterm infants with bronchopulmonary dysplasia.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  3. Dexmedetomidine and midazolam usage and association with BSRI scores in preterm infants with chronic respiratory failure.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  4. Clinician knowledge, attitudes, and perceptions of delirium in patients with grade 3 bronchopulmonary dysplasia: A national survey.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  5. Interdisciplinary clinical bronchopulmonary dysplasia programs: development, evolution, and maturation.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Review
  6. A quality improvement initiative to reduce excess inhaled therapy use in the neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  7. Review
  8. Article
  9. Review
  10. Pulmonary vasodilator use in very preterm infants in United States children's hospitals.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Observational
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. A review and guide to nutritional care of the infant with established bronchopulmonary dysplasia.Journal of perinatology : official journal of the California Perinatal Association · 2023
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Nicolas A BamatDivision of Neonatology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. bamatn@email.chop.edu.ORCID http://orcid.org/0000-0001-6427-093X
Haresh KirpalaniDivision of Neonatology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Chris FeudtnerDepartment of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Erik A JensenDivision of Neonatology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Matthew M LaughonDepartment of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Huayan ZhangDivision of Neonatology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Heather M MonkPharmacy Services, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Molly PassarellaCenter for Outcomes Research, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Scott A LorchDivision of Neonatology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Children's Hospital of Philadelphia · USUniversity of North Carolina at Chapel Hill · US

Funding

Pediatric Hospital Epidemiology and Outcomes Research Training ProgramT32HD060550 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI Christopher Peter Bonafide, John Chris Feudtner · 2010 to 2026
$6.8M
Microbiome of the Airway and the Risk for Bronchopulmonary Dysplasia in the Lungs of Extreme Preterms: The MARBLE StudyK23HL136843 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI JENSEN, ERIK ALLEN · 2018 to 2022
$819k
Mentorship of Early-Career Clinicians in Bronchopulmonary Dysplasia Drug TherapiesK24HL143283 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LAUGHON, MATTHEW · 2019 to 2023
$613k
NHLBI NIH HHS K23 HL136843NHLBI NIH HHS K24 HL143283NICHD NIH HHS T32 HD060550U.S. Department of Health & Human Services | National Institutes of Health (NIH) 2T32HD060550-06U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) K23HL136843
6 · The paper itself

Abstract

objectiveTo identify the number of cumulative medication exposures and most frequently used medications in infants with severe BPD. STUDY

designWe performed a retrospective cohort study in infants with severe BPD admitted to United States children's hospitals. We measured cumulative medication exposures in individual subjects and between-center variation after adjustment for infant characteristics. We then identified the specific medications and therapeutic classes with the highest rates of use.

resultsIn 3252 subjects across 43 hospitals, we identified a median (interquartile range) of 30 (17-45) cumulative medication exposures per infant. The adjusted mean number of medication exposures varied between centers (p < 0.0001), with a range of 22-50. Diuretics and furosemide were the most frequently prescribed therapeutic class and specific medication for the management of severe BPD.

conclusionsInfants with severe BPD are exposed to alarming number of medications of unclear efficacy and safety, with marked variation between center.

Indexed as

Bronchopulmonary DysplasiaDrug UtilizationFemaleGestational AgeHospitalizationHospitals, PediatricHumansInfant, NewbornInfant, PrematureIntensive Care Units, NeonatalMaleRetrospective StudiesUnited States

Identifiers

PMID31227785
PMCPMC6713592
OpenAlexW2952518646

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.