ArticleScientific reports2019
Dosing and formulation of antenatal corticosteroids for fetal lung maturation and gene expression in rhesus macaques.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Different corticosteroids and regimens for accelerating fetal lung maturation for babies at risk of preterm birth.The Cochrane database of systematic reviews · 2022Pooled it
- Pharmacokinetics and Pharmacodynamics of Intramuscular and Oral Betamethasone and Dexamethasone in Reproductive Age Women in India.Clinical and translational science · 2020Trial
- Glucocorticoids in pregnancy: a master-switch for fetal maturation.Endocrine reviews · 2026Review
- Article
- Megalin (LRP2), prenatal betamethasone, and injury susceptibility in the developing kidney.bioRxiv : the preprint server for biology · 2026Article
- Reduced NLRP3, AIM2 and NLRC4 inflammasome activity in cord blood of extremely preterm infants.Frontiers in pediatrics · 2026Article
- Transdermal delivery of antenatal steroids to promote fetal lung maturation: Proof of principle data from sheep and non-human primate models.BMC medicine · 2025Article
- Nasal CPAP increases alveolar number in a rhesus monkey model of moderate prematurity.The European respiratory journal · 2025Article
- Perinatal glucocorticoid sensitivity in the preterm newborn: molecular mechanisms, endogenous determinants, and clinical implications.Frontiers in endocrinology · 2025Review
- Association of antenatal corticosteroids with mortality and morbidities in very preterm infants born to women with hypertensive disorders of pregnancy: a multicenter prospective cohort study.BMC pregnancy and childbirth · 2024Article
- Structural connectivity at term equivalent age and language in preterm children at 2 years corrected.Brain communications · 2024Article
- A Reduction in Antenatal Steroid Dose Was Associated with Reduced Cardiac Dysfunction in a Sheep Model of Pregnancy.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Molecular mechanisms underlying adverse effects of dexamethasone and betamethasone in the developing cardiovascular system.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023Article
- Fetal maturation revealed by amniotic fluid cell-free transcriptome in rhesus macaques.JCI insight · 2022Article
- Validation of reference genes for whole blood gene expression analysis in cord blood of preterm and full-term neonates and peripheral blood of healthy adults.BMC genomics · 2021Article
- Antenatal corticosteroids: a reappraisal of the drug formulation and dose.Pediatric research · 2021Review
- Prenatal inflammation enhances antenatal corticosteroid-induced fetal lung maturation.JCI insight · 2020Article
- Glucocorticoid regulates mesenchymal cell differentiation required for perinatal lung morphogenesis and function.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- Article
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
Antenatal corticosteroids (ANS) are the major intervention to decrease respiratory distress syndrome and mortality from premature birth and are standard of care. The use of ANS is expanding to include new indications and gestational ages, although the recommended dosing was never optimized. The most widely used treatment is two intramuscular doses of a 1:1 mixture of betamethasone-phosphate (Beta-P) and betamethasone-acetate (Beta-Ac) - the clinical drug. We tested in a primate model the efficacy of the slow release Beta-Ac alone for enhancing fetal lung maturation and to reduce fetal corticosteroid exposure and potential toxic effects. Pregnant rhesus macaques at 127 days of gestation (80% of term) were treated with either the clinical drug (0.25 mg/kg) or Beta-Ac (0.125 mg/kg). Beta-Ac alone increased lung compliance and surfactant concentration in the fetal lung equivalently to the clinical drug. By transcriptome analyses the early suppression of genes associated with immune responses and developmental pathways were less affected by Beta-Ac than the clinical drug. Promoter and regulatory analysis prediction identified differentially expressed genes targeted by the glucocorticoid receptor in the lung. At 5 days the clinical drug suppressed genes associated with neuronal development and differentiation in the fetal hippocampus compared to control, while low dose Beta-Ac alone did not. A low dose ANS treatment with Beta-Ac should be assessed for efficacy in human trials.
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Registered trials
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