ArticleScientific reports2019
Automated monitoring of behaviour in zebrafish after invasive procedures.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- How to Make Your Fish Work for You: Tips from Ethology and Ecology for Finding Appropriate Unconditioned Stimuli for Learning Studies withAnimals : an open access journal from MDPI · 2026Article
- A framework for a low-cost system of automated gate control in assays of spatial cognition in fishes.Journal of fish biology · 2025Article
- Advancing Zebrafish (Veterinary sciences · 2025Review
- Pain management in zebrafish : Report from a FELASA Working Group.Laboratory animals · 2024Review
- Non-Lethal Detection ofViruses · 2023Article
- Reversal of Neuralgia Effect of Beta Carotene in Streptozotocin-Associated Diabetic Neuropathic Pain in Female Zebrafish via Matrix Metalloprotease-13 Inhibition.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Article
- Article
- Improving zebrafish laboratory welfare and scientific research through understanding their natural history.Biological reviews of the Cambridge Philosophical Society · 2022Review
- The Use of Zebrafish as a Non-traditional Model Organism in Translational Pain Research: The Knowns and the Unknowns.Current neuropharmacology · 2022Article
- Zebrafish Is a Powerful Tool for Precision Medicine Approaches to Neurological Disorders.Frontiers in molecular neuroscience · 2022Review
- Exploiting animal personality to reduce chronic stress in captive fish populations.Frontiers in veterinary science · 2022Article
- Anaesthesia of laboratory, aquaculture and ornamental fish: Proceedings of the first LASA-FVS Symposium.Laboratory animals · 2021Article
- Zebrafish automatic monitoring system for conditioning and behavioral analysis.Scientific reports · 2021Article
- Housing, Husbandry and Welfare of a "Classic" Fish Model, the Paradise Fish (Animals : an open access journal from MDPI · 2021Article
- Identification of Individual Zebrafish (Animals : an open access journal from MDPI · 2021Article
- Current Methods to Investigate Nociception and Pain in Zebrafish.Frontiers in neuroscience · 2021Review
- Skin swabbing is a refined technique to collect DNA from model fish species.Scientific reports · 2020Article
- From Land to Water: Taking Fish Welfare Seriously.Animals : an open access journal from MDPI · 2020Article
- Acute and chronic stress prevents responses to pain in zebrafish: evidence for stress-induced analgesia.The Journal of experimental biology · 2020Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Fish are used in a variety of experimental contexts often in high numbers. To maintain their welfare and ensure valid results during invasive procedures it is vital that we can detect subtle changes in behaviour that may allow us to intervene to provide pain-relief. Therefore, an automated method, the Fish Behaviour Index (FBI), was devised and used for testing the impact of laboratory procedures and efficacy of analgesic drugs in the model species, the zebrafish. Cameras with tracking software were used to visually track and quantify female zebrafish behaviour in real time after a number of laboratory procedures including fin clipping, PIT tagging, and nociceptor excitation via injection of acetic acid subcutaneously. The FBI was derived from activity and distance swum measured before and after these procedures compared with control and sham groups. Further, the efficacy of a range of drugs with analgesic properties to identify efficacy of these agents was explored. Lidocaine (5 mg/L), flunixin (8 mg/L) and morphine (48 mg/L) prevented the associated reduction in activity and distance swum after fin clipping. From an ethical perspective, the FBI represents a significant refinement in the use of zebrafish and could be adopted across a wide range of biological disciplines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.